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[与溃疡性结肠炎相关的无菌性皮肤乳房脓肿]

[Aseptic cutaneous breast abscesses associated with ulcerative colitis].

作者信息

Sallé de Chou C, Ortonne N, Hivelin M, Wolkenstein P, Chosidow O, Valeyrie-Allanore L

机构信息

Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.

Université Paris Est Créteil (UPEC), faculté de médecine, 8, rue du Général-Sarrail, 94000 Créteil, France.

出版信息

Ann Dermatol Venereol. 2016 Feb;143(2):139-43. doi: 10.1016/j.annder.2015.10.579. Epub 2016 Feb 3.

Abstract

BACKGROUND

Inflammatory bowel diseases are associated with a broad range of cutaneous lesions. Herein we report the first case of aseptic skin abscesses associated with ulcerative colitis.

CASE REPORT

Since March 2008, a 40-year-old woman presented with bilateral mammary abscesses, relapsing despite repeated antibiotic treatment. She was followed for ulcerative colitis diagnosed in 2011 by means of a rectal biopsy. Despite four surgical procedures, there was no improvement in her mammary abscesses and bilateral mastectomy was then proposed because of the persistent symptoms. Her general state of health remained stable. Clinically, there were bilateral inflammatory nodes with fistulae and pus. These lesions were extremely painful. Mild inflammatory syndrome was noted, but the immunological tests revealed nothing of note. Bacteriological, parasitological and mycological tests on biopsy specimens were negative. Histological examination of a surgical biopsy revealed lymphoplasmacytic infiltration of the dermis and subcutis with altered polymorphonuclear cells and epithelioid granuloma. The CT-scan showed no other remote lesions. The final diagnosis was cutaneous aseptic abscess syndrome associated with ulcerative colitis. Colchicine 1mg/day was initiated and resulted in regression of the skin lesions, with complete remission at one year of follow-up.

DISCUSSION

Aseptic abscess syndrome must be considered in the event of recurrent aseptic cutaneous abscesses which may be associated with inflammatory bowel disease. Surgery should be avoided and treatment should be based on suitable drug therapy.

摘要

背景

炎症性肠病与多种皮肤病变相关。在此,我们报告首例与溃疡性结肠炎相关的无菌性皮肤脓肿病例。

病例报告

自2008年3月起,一名40岁女性出现双侧乳腺脓肿,尽管反复使用抗生素治疗仍复发。她于2011年经直肠活检确诊为溃疡性结肠炎并接受随访。尽管进行了四次外科手术,其乳腺脓肿仍无改善,由于症状持续,随后建议行双侧乳房切除术。她的总体健康状况保持稳定。临床上,双侧有炎性结节伴瘘管及脓液。这些病变极为疼痛。观察到轻度炎症综合征,但免疫检查未发现异常。活检标本的细菌学、寄生虫学和真菌学检查均为阴性。手术活检的组织学检查显示真皮和皮下组织有淋巴细胞和浆细胞浸润,多形核细胞改变及上皮样肉芽肿。CT扫描未显示其他远处病变。最终诊断为与溃疡性结肠炎相关的皮肤无菌性脓肿综合征。开始使用秋水仙碱1毫克/天,皮肤病变消退,随访一年完全缓解。

讨论

对于可能与炎症性肠病相关的复发性无菌性皮肤脓肿,必须考虑无菌性脓肿综合征。应避免手术,治疗应基于合适的药物治疗。

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