右侧颞下颌关节滑膜软骨瘤病累及中颅窝：1例术后7年随访及细胞增殖活性生物标志物表达的病例报告
Synovial chondromatosis of the right side temporomandibular joint extending to the middle cranial fossa: A case report with 7-year postoperative follow up and expression of a biomarker of cell proliferative activity.
作者信息
Yoshitake Hiroyuki, Kayamori Kou, Wake So, Sato Fumiaki, Kino Koji, Harada Kiyoshi
机构信息
Department of Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Oral Pathology, Graduate School, Tokyo Medical and Dental University, Japan.
出版信息
Int J Surg Case Rep. 2016;20:133-7. doi: 10.1016/j.ijscr.2016.01.026. Epub 2016 Jan 25.
INTRODUCTION
Synovial chondromatosis of the temporomandibular joint (TMJ) with cranial extension is rare. Here, we report 7-year follow-up of a case with immunohistochemical examination of cell proliferative activity.
PRESENTATION OF CASE
The patient was a 72-year-old man. Severe bone resorption of the glenoid fossa was apparent on CT images. Pathological findings by biopsy led to diagnosis of synovial chondromatosis of the right side TMJ. Extirpation of the tumor was performed via temporopreauricular incision under general anesthesia. PCNA expression was examined by immunohistochemical analysis. The lesion had penetrated into the middle cranial fossa, but the cranial dura mater was intact. Expression of PCNA was confirmed.
DISCUSSION
The PCNA expression suggested that growth activity caused expansion of the lesion to the skull base.
CONCLUSION
We were able to follow up this case for a long period without recurrence postoperatively.
引言
颞下颌关节滑膜软骨瘤伴颅骨扩展较为罕见。在此，我们报告一例经免疫组织化学检查细胞增殖活性的病例的7年随访情况。
病例介绍
患者为一名72岁男性。CT图像显示关节盂严重骨质吸收。活检的病理结果确诊为右侧颞下颌关节滑膜软骨瘤。在全身麻醉下通过颞部耳前切口进行肿瘤切除。通过免疫组织化学分析检测增殖细胞核抗原（PCNA）的表达。病变已侵入中颅窝，但硬脑膜完整。证实有PCNA表达。
讨论
PCNA表达提示生长活性导致病变向颅底扩展。
结论
我们能够对该病例进行长期随访，术后无复发。
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