Kahveci Hasan, Tayman Cuneyt, Laoğlu Fuat, Celik Hüseyin Tugrul, Kavas Nazan, Kılıç Ömer, Aydemir Salih
Division of Neonatal Intencive Care Unit, Erzurum District Training and Research Hospital, Erzurum, Turkey.
Department of Neonatology, Denizli T.C. Public Health Hospital, 2010, Denizli, Turkey.
Indian J Clin Biochem. 2016 Mar;31(1):38-42. doi: 10.1007/s12291-015-0494-0. Epub 2015 Apr 28.
Infants with respiratory distress syndrome (RDS) may suffer from severe hypoxia, asphyxia. In this study, we aimed to evaluate serum ischemia-modified albumin (IMA) level as a diagnostic marker for hypoxia in preterm infants with RDS. Thirty-seven premature newborns with RDS were allocated as the study group and 42 healthy preterm neonates were selected as the control group. IMA was measured as absorbance unit (ABSU) in human serum with colorimetric assay method which is based on reduction in albumin cobalt binding. IMA levels were significantly higher in neonates with RDS as compared to the control group (P < 0.001). Cut-off value of IMA (ABSU) was 0.72, the sensitivity level was 91.9 %, the specificity was 78.6 %, positive predictive value was 79.1 % and negative predictive value was 91.7 % at RDS. Area under curve values was 0.93 (P < 0.001; 95 % CI, 0.88-0.98) in the receiver operating characteristic curve. We concluded that elevated blood IMA levels might be accepted as a useful marker for hypoxia in newborn with RDS.
患有呼吸窘迫综合征（RDS）的婴儿可能会遭受严重缺氧、窒息。在本研究中，我们旨在评估血清缺血修饰白蛋白（IMA）水平作为RDS早产儿缺氧的诊断标志物。将37例患有RDS的早产新生儿分配为研究组，选择42例健康早产新生儿作为对照组。采用基于白蛋白钴结合减少的比色测定法，以吸光度单位（ABSU）来测量人血清中的IMA。与对照组相比，RDS新生儿的IMA水平显著更高（P < 0.001）。在RDS时，IMA（ABSU）的截断值为0.72，灵敏度为91.9%，特异性为78.6%，阳性预测值为79.1%，阴性预测值为91.7%。在受试者工作特征曲线中，曲线下面积值为0.93（P < 0.001；95%CI，0.88 - 0.98）。我们得出结论，血液中IMA水平升高可被视为RDS新生儿缺氧的有用标志物。
