Paul Siba Prosad, McVeigh Lauren, Gil-Zaragozano Elena, Basude Dharamveer
Bristol Royal Hospital for Children.
Nurs Child Young People. 2016 Feb;28(1):18-24. doi: 10.7748/ncyp.28.1.18.s28.
Coeliac disease is an autoimmune condition caused by the ingestion of gluten-containing foods and affects about 1% of children and young people in the UK. Classic symptoms include diarrhoea, bloating, weight loss and abdominal pain. However, extra-intestinal manifestations, such as iron deficiency anaemia, faltering growth, delayed puberty and mouth ulcers, are increasingly being recognised. Some children have an increased risk of developing coeliac disease, such as a strong family history, certain genetic conditions and type 1 diabetes, therefore there is a need for increased awareness and early diagnosis before symptoms occur. If coeliac disease is suspected, a child should have serological screening with anti-tissue transglutaminase titres. Diagnosis is traditionally confirmed by a small bowel biopsy while the child remains on a 'normal' diet that does not exclude gluten. More recently, for a selective group of children, modification of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines has enabled non-biopsy (serological) diagnosis of coeliac disease. Children's nurses have an important role in recognising and diagnosing coeliac disease earlier as well as offering ongoing dietary support. Enabling children to maintain a gluten-free diet is essential for general wellbeing and preventing long-term complications.
乳糜泻是一种由摄入含麸质食物引起的自身免疫性疾病,在英国约1%的儿童和年轻人中受到影响。典型症状包括腹泻、腹胀、体重减轻和腹痛。然而,诸如缺铁性贫血、生长发育迟缓、青春期延迟和口腔溃疡等肠外表现越来越受到认可。一些儿童患乳糜泻的风险增加,如家族病史强烈、某些遗传疾病和1型糖尿病,因此需要提高认识并在症状出现前进行早期诊断。如果怀疑患有乳糜泻,儿童应进行抗组织转谷氨酰胺酶滴度的血清学筛查。传统上,诊断通过小肠活检来确认,同时儿童保持不排除麸质的“正常”饮食。最近,对于一部分特定儿童,欧洲儿科胃肠病学、肝病学和营养学会指南的修订使得乳糜泻的非活检(血清学)诊断成为可能。儿童护士在更早地识别和诊断乳糜泻以及提供持续的饮食支持方面发挥着重要作用。使儿童保持无麸质饮食对于总体健康和预防长期并发症至关重要。