UGT1A1*6、UGT1A1*28和ABCB1-3435C>T基因多态性对中国癌症患者伊立替康所致毒性的影响。
Effects of UGT1A1*6, UGT1A1*28, and ABCB1-3435C>T polymorphisms on irinotecan induced toxicity in Chinese cancer patients.
作者信息
Yan Liang, Wang Xiao-Fei, Wei Lu-Man, Nie Ya-Li, Liu Jing-Yang, Zhang Li-Rong
出版信息
Int J Clin Pharmacol Ther. 2016 Mar;54(3):193-9. doi: 10.5414/CP202442.
OBJECT
The aim of this study was to investigate whether UGT1A1*6/*28 or ABCB1-3435C>T polymorphisms affect irinotecan-induced severe diarrhea and neutropenia in Chinese cancer patients.
METHODS
A total of 157 cancer patients was enrolled in this study and the genotypes of UGT1A1*6/28 and ABCB1-3435C>T polymorphisms were analyzed by PCRSanger sequence. The relationship between UGT1A16/*28 and ABCB1-3435C>T polymorphisms and irinotecan induced severe diarrhea and neutropenia were analyzed.
RESULTS AND CONCLUSION
UGT1A16 and UGT1A128 polymorphisms were associated with severe neutropenia (p = 0.025, p = 0.022, respectively) but not diarrhea (p = 0.343, p = 0.185, respectively), and ABCB1- 3435C>T polymorphism was not associated with irinotecan induced severe toxicities (p = 0.457, p = 0.161, respectively).
目的
本研究旨在调查在中国癌症患者中，UGT1A1*6/*28或ABCB1-3435C>T基因多态性是否会影响伊立替康诱发的严重腹泻和中性粒细胞减少。
方法
本研究共纳入157例癌症患者，采用聚合酶链反应-桑格测序法分析UGT1A1*6/28和ABCB1-3435C>T基因多态性。分析UGT1A16/*28和ABCB1-3435C>T基因多态性与伊立替康诱发的严重腹泻和中性粒细胞减少之间的关系。
结果与结论
UGT1A16和UGT1A128基因多态性与严重中性粒细胞减少相关（分别为p = 0.025，p = 0.022），但与腹泻无关（分别为p = 0.343，p = 0.185），且ABCB1-3435C>T基因多态性与伊立替康诱发的严重毒性无关（分别为p = 0.457，p = 0.161）。
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