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同类相比:是时候对新生儿营养与生长研究进行标准化报告了。

Comparing apples with apples: it is time for standardized reporting of neonatal nutrition and growth studies.

作者信息

Cormack Barbara E, Embleton Nicholas D, van Goudoever Johannes B, Hay William W, Bloomfield Frank H

机构信息

Liggins Institute, The University of Auckland, Auckland, New Zealand.

Newborn Services, Auckland City Hospital, Auckland, New Zealand.

出版信息

Pediatr Res. 2016 Jun;79(6):810-20. doi: 10.1038/pr.2016.26. Epub 2016 Feb 11.

Abstract

The ultimate goal of neonatal nutrition care is optimal growth, neurodevelopment, and long-term health for preterm babies. International consensus is that increased energy and protein intakes in the neonatal period improve growth and neurodevelopment, but after more than 100 y of research the optimum intakes of energy and protein remain unknown. We suggest an important factor contributing to the lack of progress is the lack of a standardized approach to reporting nutritional intake data and growth in the neonatal literature. We reviewed randomized controlled trials and observational studies documented in MEDLINE and the Web of Science from 2008 to 2015 that compared approximately 3 vs. 4 g.kg(-1).d(-1) protein for preterm babies in the first month after birth. Consistency might be expected in the calculation of nutritional intake and assessment of growth outcomes in this relatively narrow scope of neonatal nutrition research. Twenty-two studies were reviewed. There was substantial variation in methods used to estimate and calculate nutritional intakes and in the approaches used in reporting these intakes and measures of infant growth. Such variability makes comparisons amongst studies difficult and meta-analysis unreliable. We propose the StRONNG Checklist-Standardized Reporting Of Neonatal Nutrition and Growth to address these issues.

摘要

新生儿营养护理的最终目标是实现早产儿的最佳生长、神经发育和长期健康。国际共识认为,新生儿期能量和蛋白质摄入量的增加可改善生长和神经发育,但经过100多年的研究,能量和蛋白质的最佳摄入量仍然未知。我们认为,导致进展不足的一个重要因素是新生儿文献中缺乏报告营养摄入数据和生长情况的标准化方法。我们回顾了2008年至2015年发表在MEDLINE和科学网的随机对照试验和观察性研究,这些研究比较了出生后第一个月早产儿蛋白质摄入量约为3 vs. 4 g.kg(-1).d(-1) 的情况。在这个相对狭窄的新生儿营养研究范围内,营养摄入量的计算和生长结果的评估可能会有一致性。共审查了22项研究。在估计和计算营养摄入量的方法以及报告这些摄入量和婴儿生长指标的方法上存在很大差异。这种变异性使得研究之间的比较变得困难,荟萃分析也不可靠。我们提出了StRONNG清单——新生儿营养与生长标准化报告,以解决这些问题。

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