The Impact of Methylprednisolone Pulses during Relapses of Multiple Sclerosis on the Kinetics of Anti-Interferon-Beta Antibodies.

作者信息

Giantzi Virginia, Karapanayiotides Theodoros, Lagoudaki Roza, Poulatsidou Kyriaki-Nefeli, Lourbopoulos Athanasios, Daniilidis Michail, Taskos Nikolaos, Milonas Ioannis, Grigoriadis Nikolaos

机构信息

2nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

出版信息

Eur Neurol. 2016;75(1-2):82-8. doi: 10.1159/000444319. Epub 2016 Feb 12.

DOI:10.1159/000444319

PMID:26867030

Abstract

BACKGROUND/AIMS: We assessed the, hitherto unknown, impact of intravenous methylprednisolone (ivMP) pulses during relapses of multiple sclerosis (MS) on the kinetics of anti-interferon-beta neutralizing antibodies (Nabs) and binding antibodies (Babs).

METHODS

Babs (ELISA) and Nabs (antiviral cytopathic effect assay) titers were evaluated before, immediately after and at 1 month following ivMP in 60 MS patients.

RESULTS

ivMP reduces Nabs and Babs titers for at least 1 month. Baseline titers determine Nabs and Babs seronegativity at the end of ivMP. Clinical response to ivMP tends to be better in Nabs(+) patients.

CONCLUSION

Sampling for Nabs/Babs should be avoided during or shortly after ivMP to avoid transient positive or negative results that may obscure the decision to switch treatment.

摘要