Zhou Qian, Tang Cheng, Zhao Ke-Wei, Xiong Yan-Li, Chen Shu, Xu Wen-Jing, Lei Xin
Research Institute of Surgery and Daping Hospital, Cancer Center, Third Military Medical University, Chongqing, China.
Clinics (Sao Paulo). 2016 Jan;71(1):10-6. doi: 10.6061/clinics/2016(01)03.
The aim of this study was to determine the efficacy of 252Californium neutron intracavitary brachytherapy using a two-channel Y applicator combined with external beam radiotherapy for the treatment of endometrial cancer.
Thirty-one patients with stage I-III endometrial cancer were recruited for this study. The stage I patients received only 252Californium neutron intracavitary brachytherapy with a two-channel applicator. The stage II and III patients received both 252Californium neutron intracavitary brachytherapy using a two-channel applicator and parallel-opposed whole pelvic radiotherapy.
The five-year local control rate was 80.6% (25/31), the overall survival rate was 51.6% (16/31), and the disease-free survival rate was 54.8% (17/31). The incidence of serious late complications was 12.9% (4/31).
252Californium neutron intracavitary brachytherapy using a two-channel applicator combined with external beam radiotherapy was effective for treating endometrial cancer and the incidence of serious late complications related to this combination was within an acceptable range.
本研究旨在确定使用双通道Y型施源器的²⁵²锎中子腔内近距离放疗联合外照射放疗治疗子宫内膜癌的疗效。
本研究招募了31例I - III期子宫内膜癌患者。I期患者仅接受使用双通道施源器的²⁵²锎中子腔内近距离放疗。II期和III期患者接受使用双通道施源器的²⁵²锎中子腔内近距离放疗和平行相对的全盆腔放疗。
五年局部控制率为80.6%（25/31），总生存率为51.6%（16/31），无病生存率为54.8%（17/31）。严重晚期并发症的发生率为12.9%（4/31）。
使用双通道施源器的²⁵²锎中子腔内近距离放疗联合外照射放疗治疗子宫内膜癌有效，且与此联合治疗相关的严重晚期并发症发生率在可接受范围内。
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