线粒体功能障碍与衰老相遇。
Mitochondrial Dysfunction Meets Senescence.
机构信息
Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, UK.
Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, UK.
出版信息
Trends Biochem Sci. 2016 Mar;41(3):207-209. doi: 10.1016/j.tibs.2016.01.005. Epub 2016 Feb 11.
Cellular senescence and mitochondrial dysfunction are hallmarks of ageing, but until now their relationship has not been clear. Recent work by Wiley et al. shows that mitochondrial defects can cause a distinct senescence phenotype termed MiDAS (mitochondrial dysfunction-associated senescence). MiDAS has a specific secretome that is able to drive some of the aging phenotypes. These findings suggest novel therapeutic opportunities for treating age-related pathologies.
细胞衰老和线粒体功能障碍是衰老的标志，但到目前为止，它们之间的关系还不清楚。最近，Wiley 等人的研究表明，线粒体缺陷可导致一种特殊的衰老表型，称为 MiDAS（线粒体功能障碍相关衰老）。MiDAS 具有特定的分泌组，能够驱动部分衰老表型。这些发现为治疗与年龄相关的病理提供了新的治疗机会。
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