Hanai T, Yura J, Ogino K, Hori K, Suzuki T
First Department of Surgery, Nagoya City University Medical School, Japan.
Jpn J Surg. 1989 Sep;19(5):556-62. doi: 10.1007/BF02471663.
In a study using rats, we investigated whether liver damage induced by endotoxemia in obstructive jaundice is associated with thromboxane (TX) in order to acertain whether its vasoconstrictive and platelet aggregating properties play a role in reducing liver blood flow. The rats were divided into the following 5 groups; a control group, an endotoxin (Et) group, a bile duct ligation (BDL) group, a bile duct ligation and endotoxin (BDL + Et) group and an OKY046 (Thromboxane synthetase inhibitor) treated bile duct ligation + endotoxin (OKY-BDL + Et) group. The blood TXB2 levels in the Et, BDL and BDL + Et groups were higher than those in the control group. The liver TXB2 levels in the Et and BDL + Et groups were also higher than those in the control group. Liver phospholipids and liver blood flow decreased in the BDL + Et group, whereas in the OKY-BDL + Et group they returned close to the control group levels by decreasing the TXB2 levels in both the liver and blood to normal. These results suggest that the high level of TX in the blood and liver tissue may further aggrevate the liver during endotoxemia in obstructive jaundice by inhibiting liver blood flow.
在一项以大鼠为对象的研究中，我们探究了阻塞性黄疸内毒素血症所致肝损伤是否与血栓素（TX）有关，以确定其血管收缩和血小板聚集特性是否在减少肝血流量中发挥作用。大鼠被分为以下5组：对照组、内毒素（Et）组、胆管结扎（BDL）组、胆管结扎加内毒素（BDL + Et）组以及用OKY046（血栓素合成酶抑制剂）处理的胆管结扎加内毒素（OKY - BDL + Et）组。Et组、BDL组和BDL + Et组的血液TXB2水平高于对照组。Et组和BDL + Et组的肝脏TXB2水平也高于对照组。BDL + Et组肝脏磷脂和肝血流量降低，而在OKY - BDL + Et组中，通过将肝脏和血液中的TXB2水平降至正常，它们恢复到接近对照组的水平。这些结果表明，血液和肝组织中高水平的TX可能通过抑制肝血流量在阻塞性黄疸内毒素血症期间进一步加重肝脏损伤。
