Meng Xia, Liu Gaifang, Wu Jing, Kong Congcong, Zhao Liwei, Zhu Xinying, Ji Chenguang, Yang Liang
Department of Gastroenterology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Zhonghua Yi Xue Za Zhi. 2016 Jan 26;96(4):270-2. doi: 10.3760/cma.j.issn.0376-2491.2016.04.008.
To evaluate the resistance of Helicobacter pylori (H.pylori) clinical isolates to various antibiotics, in order to guide rational drug use in Hebei Province.
From January 2014 to July 2015, 260 patients with H. pylori infection who had not received eradication treatment were enrolled in Third Hospital of Hebei Medical University. Gastric mucosa biopsy tissue samples were collected from these patients before treatment for isolation and culture of H. pylori. Kirby-Bauer method was used to detect drug-resistance rate of the H. pylori clinical isolates to metronidazole, clarithromycin, amoxicillin, levofloxacin, and furazolidone.
A total of 155 H. pylori strains were isolated from tissue samples of the 260 patients (positive rate, 59.6%). The drug-resistance rate of H. pylori isolated to metronidazole, clarithromycin, amoxicillin, levofloxacin, and furazolidone was 94.2%(146/155), 21.3%(33/155), 2.6%(4/155), 5.8% (9/155), and 1.9%(3/155), respectively. There was no statistically significant difference in positive culture rate and drug-resistance rate between different sex, age, and disease category(all P>0.05).
In Hebei Province, the resistance rates of H. pylori to metronidazole and clarithromycin appear to be higher than those to amoxicillin, levofloxacin, and furazolidone.
评估幽门螺杆菌（H.pylori）临床分离株对多种抗生素的耐药性，以指导河北省的合理用药。
2014年1月至2015年7月，河北医科大学第三医院纳入260例未接受过根除治疗的幽门螺杆菌感染患者。在治疗前采集这些患者的胃黏膜活检组织样本，用于幽门螺杆菌的分离培养。采用 Kirby-Bauer 法检测幽门螺杆菌临床分离株对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星和呋喃唑酮的耐药率。
从260例患者的组织样本中共分离出155株幽门螺杆菌（阳性率为59.6%）。幽门螺杆菌对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星和呋喃唑酮的耐药率分别为94.2%（146/155）、21.3%（33/155）、2.6%（4/155）、5.8%（9/155）和1.9%（3/155）。不同性别、年龄和疾病类别之间的阳性培养率和耐药率差异均无统计学意义（均P>0.05）。
在河北省，幽门螺杆菌对甲硝唑和克拉霉素的耐药率似乎高于对阿莫西林、左氧氟沙星和呋喃唑酮的耐药率。
