Frandsen H, Berne C, Fagius J, Niklasson F, Christensen N J, Hilsted J
Department of Internal Medicine and Endocrinology, University of Copenhagen, Herlev Hospital, Denmark.
Scand J Clin Lab Invest. 1989 Oct;49(6):573-81. doi: 10.3109/00365518909089138.
Microelectrode recordings of muscle nerve sympathetic activity and measurements of venous plasma noradrenaline have indicated increased sympathetic outflow during acute hypoglycaemia. Plasma volume reduction during hypoglycaemia, as evidenced by increasing peripheral venous haematocrit might underly the sympathetic activation. To study the effect of prevention of plasma volume reduction during hypoglycaemia, saline containing albumin was infused intravenously in healthy adult volunteers during hypoglycaemia. Hypoglycaemia was induced by an intravenous injection of soluble insulin in a dose of 0.15 IU/kg body weight. Peripheral venous plasma noradrenaline concentrations were identical in experiments without and with plasma volume substitution. Muscle nerve sympathetic activity increased to the same extent during hypoglycaemia with and without plasma volume substitution. It is concluded that increased plasma noradrenaline concentrations and enhanced muscle nerve sympathetic activity during insulin-induced hypoglycaemia in man are not consequences of plasma volume reduction.
肌肉神经交感神经活动的微电极记录以及静脉血浆去甲肾上腺素的测量表明，急性低血糖期间交感神经输出增加。低血糖期间血浆量减少，表现为外周静脉血细胞比容升高，这可能是交感神经激活的基础。为了研究预防低血糖期间血浆量减少的效果，在低血糖期间对健康成年志愿者静脉输注含白蛋白的生理盐水。通过静脉注射剂量为0.15 IU/kg体重的可溶性胰岛素诱导低血糖。在无血浆量替代和有血浆量替代的实验中，外周静脉血浆去甲肾上腺素浓度相同。在有和没有血浆量替代的低血糖期间，肌肉神经交感神经活动增加的程度相同。得出的结论是，人在胰岛素诱导的低血糖期间血浆去甲肾上腺素浓度升高和肌肉神经交感神经活动增强不是血浆量减少的结果。
