Permiakov N K, Iakovlev M Iu, Mironiuk A A
Arkh Patol. 1989;51(9):3-9.
An important role in the endotoxin immobilization and transport from the intestine into the portal circulation belongs to the granulocytes which are likely able to transfer lipopolysaccharide to Kupffer cells. If the endotoxin diffusion into the mesenterial microvessels increases and (or) the portal circulation speed decreases, the interaction of lipopolysaccharide with granulocytes may become irreversible and facilitate the development of the systemic endotoxemia and the leucocyte-mediated liver damage. Intestinal flora endotoxin takes part in the liver damage pathogenesis in various forms of hepatitis, cirrhosis in various forms of hepatitis, cirrhosis and conditions followed by the circulation deficiency.
粒细胞在内毒素从肠道固定并转运至门静脉循环中起重要作用，它们可能能够将脂多糖传递给库普弗细胞。如果内毒素向肠系膜微血管的扩散增加和（或）门静脉循环速度降低，脂多糖与粒细胞的相互作用可能会变得不可逆，并促进全身性内毒素血症和白细胞介导的肝损伤的发展。肠道菌群内毒素以各种形式参与肝炎、各种形式肝炎后的肝硬化、肝硬化以及循环功能不全等疾病的肝损伤发病机制。
