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重度主动脉瓣狭窄管理方面的进展

Advances in the management of severe aortic stenosis.

作者信息

O'Sullivan K E, Bargenda S, Sugrue D, Hurley J

机构信息

Department of Cardiothoracic Surgery, Mater Private Hospital, Eccles St., Dublin 7, Ireland.

Department of Cardiology, Mater Private Hospital, Dublin, Ireland.

出版信息

Ir J Med Sci. 2016 May;185(2):309-17. doi: 10.1007/s11845-016-1417-7. Epub 2016 Feb 17.

Abstract

BACKGROUND

Recent developments in the management of severe aortic stenosis have resulted in a paradigm shift in the way we view the condition. Patients previously denied intervention in the form of surgical aortic valve replacement (SAVR) are now candidates for transcatheter aortic valve implantation and the risk and age profiles of those undergoing SAVR are rising with the ageing population. This review article is designed to provide an overview of developments in the surgical management of severe aortic stenosis. We also discuss the expanding role of minimally invasive surgical approaches to outline the current techniques available to treat patients with severe aortic stenosis.

METHODS

PubMed was searched using the terms 'severe aortic stenosis', 'surgical aortic valve replacement', 'transcatheter aortic valve replacement', 'mechanical aortic valve replacement' and 'sutureless aortic valve replacement'. Selection of articles was based on peer review, journal and relevance. Where possible articles from high-impact factor peer review journals were included.

RESULTS

Minimally invasive operative approaches include mini-sternotomy and mini-thoracotomy. Sutureless aortic prostheses reduce aortic cross-clamp time and cardiopulmonary bypass time; however, long-term follow-up data are unavailable at this time. Mechanical prostheses are advised for those under 60.

CONCLUSION

Multiple advances in the surgical management of aortic stenosis have occured in the past decade. An evolving spectrum of surgical and transcatheter interventions is now available depending on patient age and operative risk.

摘要

背景

重度主动脉瓣狭窄管理方面的最新进展导致了我们对该疾病看法的范式转变。以前被拒绝接受外科主动脉瓣置换术(SAVR)这种干预形式的患者,现在成为了经导管主动脉瓣植入术的候选对象,并且随着人口老龄化,接受SAVR的患者的风险和年龄分布也在上升。这篇综述文章旨在概述重度主动脉瓣狭窄外科治疗的进展。我们还讨论了微创外科手术方法不断扩大的作用,以概述目前可用于治疗重度主动脉瓣狭窄患者的技术。

方法

使用“重度主动脉瓣狭窄”“外科主动脉瓣置换术”“经导管主动脉瓣置换术”“机械主动脉瓣置换术”和“无缝合主动脉瓣置换术”等术语在PubMed上进行检索。文章的选择基于同行评审、期刊和相关性。尽可能纳入来自高影响因子同行评审期刊的文章。

结果

微创术式包括微创胸骨切开术和微创胸廓切开术。无缝合主动脉假体可减少主动脉阻断时间和体外循环时间;然而,目前尚无长期随访数据。建议60岁以下患者使用机械假体。

结论

在过去十年中,主动脉瓣狭窄的外科治疗取得了多项进展。现在根据患者年龄和手术风险,有一系列不断发展的外科和经导管干预手段可供选择。

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