Wang Jinsong, Li Qing, Cheng Xue, Xiong Kemei, Qi Qiong, Huang Wenbin
Department of Pathology, Nanjing Hospital (Nanjing First Hospital), Nanjing Medical University, Nanjing 210006, China.
Department of Pathology, Nanjing Hospital (Nanjing First Hospital), Nanjing Medical University, Nanjing 210006, China; E-mail:
Zhonghua Bing Li Xue Za Zhi. 2015 Dec;44(12):874-8.
To study the diagnostic value of HNF-1β and Napsin A for ovarian clear cell carcinomas, serous carcinomas, endometrioid adenocarcinomas and metastatic Krukenberg tumors.
Immunohistochemical EnVision method was used to detect the expression of HNF-1β and Napsin A in 38 cases of ovarian clear cell carcinoma, 30 cases of high-grade serous carcinoma, 22 cases of endometrioid adenocarcinoma and 16 cases of metastatic Krukenberg tumor. Expression of HNF-1β and Napsin A were compared, and sensitivity and specificity of clear cell carcinoma of the ovary were analysed.
The positive rate of HNF-1β in the ovarian clear cell carcinoma was 100%(38/38), higher than those in high-grade serous carcinoma and endometrioid adenocarcinoma (P<0.05), although significant difference was not observed from that of metastatic Krukenberg tumor (P>0.05). Napsin A expressed in 97.4% (37/38) of ovarian clear cell carcinoma, 6.7% (2/30) of high-grade serous carcinoma, 22.7% (5/22) of endometrioid adenocarcinoma. Napsin A expression in clear cell carcinoma was higher than those in high-grade serous carcinoma and endometrioid adenocarcinoma (P<0.01), and no expression of Napsin A was seen in metastatic Krukenberg tumor (P>0.05). The sensitivity and specificity of HNF-1β in the diagnosis of ovarian clear cell carcinoma were 100% and 52.9%, those of Napsin A were 97.4% and 91.2%, those of both HNF-1β and Napsin A were 97.4% and 91.2%, respectively. The sensitivity and specificity of HNF-1β or Napsin A in the diagnosis of ovarian clear cell carcinoma were 100% and 52.9%, respectively.
HNF-1β is a more sensitive marker for the diagnosis of ovarian clear cell carcinoma, whereas Napsin A is a more specific marker. The combined detection of HNF-1β and Napsin A may be helpful for the diagnosis of clear cell carcinoma of the ovary.
研究肝细胞核因子-1β（HNF-1β）和天冬氨酸蛋白酶A（Napsin A）对卵巢透明细胞癌、浆液性癌、子宫内膜样腺癌及转移性克鲁肯贝格瘤的诊断价值。
采用免疫组织化学EnVision法检测38例卵巢透明细胞癌、30例高级别浆液性癌、22例子宫内膜样腺癌及16例转移性克鲁肯贝格瘤中HNF-1β和Napsin A的表达情况。比较HNF-1β和Napsin A的表达情况，并分析卵巢透明细胞癌的敏感性和特异性。
卵巢透明细胞癌中HNF-1β的阳性率为100%（38/38），高于高级别浆液性癌和子宫内膜样腺癌（P<0.05），但与转移性克鲁肯贝格瘤相比差异无统计学意义（P>0.05）。Napsin A在97.4%（37/38）的卵巢透明细胞癌、6.7%（2/30）的高级别浆液性癌、22.7%（5/22）的子宫内膜样腺癌中表达。Napsin A在透明细胞癌中的表达高于高级别浆液性癌和子宫内膜样腺癌（P<0.01），在转移性克鲁肯贝格瘤中未见Napsin A表达（P>0.05）。HNF-1β诊断卵巢透明细胞癌的敏感性和特异性分别为100%和52.9%，Napsin A的敏感性和特异性分别为97.4%和91.2%，HNF-1β和Napsin A联合检测的敏感性和特异性分别为97.4%和91.2%。HNF-1β或Napsin A诊断卵巢透明细胞癌的敏感性和特异性分别为100%和52.9%。
HNF-1β是诊断卵巢透明细胞癌更敏感的标志物，而Napsin A是更具特异性的标志物。联合检测HNF-1β和Napsin A可能有助于卵巢透明细胞癌的诊断。
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