通过比较基因组杂交阵列（array-CGH）结果证实多步骤进展假说的肺癌：一例报告。
Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report.
作者信息
Bettio Daniela, Venci Anna, Achille Valentina, Alloisio Marco, Santoro Armando
机构信息
Cytogenetic and Medical Genetic Laboratory, Operative Unit of Clinical Investigations, Humanitas Clinical and Research Center, Milan I-20089, Italy.
Department of Thoracic Surgery, Humanitas Clinical and Research Center, Milan I-20089, Italy.
出版信息
Exp Ther Med. 2016 Jan;11(1):98-100. doi: 10.3892/etm.2015.2870. Epub 2015 Nov 16.
The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array-comparative genomic hybridization (a-CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a-CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung.
肺癌的发病机制尚未完全阐明，作为肿瘤进展和侵袭性预测指标的生物标志物仍未明确。多步骤假说认为，从腺瘤样增生（AAH）通过细支气管肺泡癌（BAC）发展为腺癌（AC），这一假说在之前一项针对单个病例的细胞遗传学研究中得到了强调。本研究报告了对先前报道病例的DNA进行的阵列比较基因组杂交（a-CGH）分析结果，该病例在一侧肺中呈现出AAH、BAC和AC。a-CGH结果用新数据证实并支持了先前的细胞遗传学观察结果，明确支持了肺部多步骤致癌过程的假说。
Zotero 插件