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[肥胖作为心房颤动的一个危险因素]

[Obesity as a risk factor for atrial fibrillation].

作者信息

Duraj Iwona, Broncel Marlena

机构信息

Department of Internal Diseases and Clinical Pharmacology Medical University of Lodz.

出版信息

Pol Merkur Lekarski. 2016 Jan;40(235):5-8.

Abstract

Atrial fibrillation (AF) and obesity is a growing problem of public health both in Poland and in the whole world. AF risk factors may be summarized as elderliness, male sex, smoking, hypertension, diabetes, obesity, coronary heart disease, heart failure, valvular heart disease, cardiac surgery. Once obesity is an independent, potentially modifiable risk factor for AF. The connection between obesity and atrial fibrillation is very up-to-date because of incremental prevalence, almost epidemic of obesity in the whole world. The probability of AF among obese patients increases with concomitant obstructive sleep apnea. Regardless many researches it hasn't been assessed yet how obesity itself predisposes to AF. It could be an effect of change in the atrial anatomy, the rise of atrial pressure, mechanical stretch, interstitial atrial fibrosis and disruption of atrial electric integrity. A great role is ascribed to inflammation, especially proinflammatory cytokines increased by adipocites of left atrial epicardial adiposity.

摘要

在波兰乃至全球,心房颤动(AF)与肥胖都是日益严重的公共卫生问题。AF的风险因素可概括为高龄、男性、吸烟、高血压、糖尿病、肥胖、冠心病、心力衰竭、心脏瓣膜病、心脏手术。肥胖曾是AF的一个独立且可能可改变的风险因素。由于全球肥胖患病率不断上升,几乎呈流行态势,肥胖与心房颤动之间的关联是一个非常新的研究热点。肥胖患者发生AF的概率会因同时存在阻塞性睡眠呼吸暂停而增加。尽管有许多研究,但肥胖本身如何导致AF尚未得到评估。这可能是心房解剖结构改变、心房压力升高、机械性拉伸、心房间质纤维化以及心房电完整性破坏的结果。炎症,尤其是左心房心外膜脂肪组织中的脂肪细胞增加促炎细胞因子,被认为起到了重要作用。

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