Wnt与YAP在人类多能干细胞神经命运中的相互作用及其对神经类器官形成的影响。
Wnt-YAP interactions in the neural fate of human pluripotent stem cells and the implications for neural organoid formation.
作者信息
Bejoy Julie, Song Liqing, Li Yan
机构信息
a Department of Chemical and Biomedical Engineering , FAMU-FSU College of Engineering, Florida State University , Tallahassee , FL , USA.
出版信息
Organogenesis. 2016 Jan 2;12(1):1-15. doi: 10.1080/15476278.2016.1140290. Epub 2016 Feb 22.
Abstract
Human pluripotent stem cells (hPSCs) have shown the ability to self-organize into different types of neural organoids (e.g., whole brain organoids, cortical spheroids, midbrain organoids etc.) recently. The extrinsic and intrinsic signaling elicited by Wnt pathway, Hippo/Yes-associated protein (YAP) pathway, and extracellular microenvironment plays a critical role in brain tissue morphogenesis. This article highlights recent advances in neural tissue patterning from hPSCs, in particular the role of Wnt pathway and YAP activity in this process. Understanding the Wnt-YAP interactions should provide us the guidance to predict and modulate brain-like tissue structure through the regulation of extracellular microenvironment of hPSCs.
摘要
人类多能干细胞（hPSCs）近来已显示出能够自我组织形成不同类型的神经类器官（例如，全脑类器官、皮质球体、中脑类器官等）的能力。Wnt信号通路、Hippo/Yes相关蛋白（YAP）信号通路以及细胞外微环境引发的外在和内在信号传导在脑组织形态发生中起着关键作用。本文重点介绍了hPSCs在神经组织模式形成方面的最新进展，特别是Wnt信号通路和YAP活性在此过程中的作用。了解Wnt-YAP相互作用应该能为我们通过调控hPSCs的细胞外微环境来预测和调节类脑组织结构提供指导。
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本文引用的文献
1
Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.调控 hPSC 来源神经元的区域特性以揭示神经疾病表型中神经元亚型的特异性。
Stem Cell Reports. 2015 Dec 8;5(6):1010-1022. doi: 10.1016/j.stemcr.2015.10.005. Epub 2015 Nov 5.
2
Differential effects of acellular embryonic matrices on pluripotent stem cell expansion and neural differentiation.无细胞胚胎基质对多能干细胞扩增和神经分化的差异影响。
Biomaterials. 2015 Dec;73:231-42. doi: 10.1016/j.biomaterials.2015.09.020. Epub 2015 Sep 12.
3
Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells.我眼前所见的是一个大脑吗？利用多能干细胞模拟人类神经发育。
Development. 2015 Sep 15;142(18):3138-50. doi: 10.1242/dev.120568.
4
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.用于预测神经毒性的人多能干细胞衍生神经构建体
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12516-21. doi: 10.1073/pnas.1516645112. Epub 2015 Sep 21.
5
Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells.Rho 信号通路调控的 YAP/TAZ 活性是维持人类胚胎干细胞长期存活和扩增的基础。
Cell Stem Cell. 2015 Oct 1;17(4):448-61. doi: 10.1016/j.stem.2015.07.009. Epub 2015 Aug 27.
6
Alternative Wnt Signaling Activates YAP/TAZ.替代性Wnt信号激活YAP/TAZ。
Cell. 2015 Aug 13;162(4):780-94. doi: 10.1016/j.cell.2015.07.013.
7
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8
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9
Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.从人类多能干细胞中生成并扩增高度纯化的运动神经元祖细胞。
Nat Commun. 2015 Mar 25;6:6626. doi: 10.1038/ncomms7626.
10
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Stem Cell Reports. 2014 Dec 9;3(6):1015-28. doi: 10.1016/j.stemcr.2014.10.004. Epub 2014 Nov 13.
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