Yao Yongming, Li Xiuhua
Trauma Research Center, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China.
Zhonghua Shao Shang Za Zhi. 2016 Feb;32(2):67-70. doi: 10.3760/cma.j.issn.1009-2587.2016.02.002.
Sepsis induced by burns, trauma, and surgical stress, remains a major cause of death of patients in ICUs. A growing number of evidence shows that sepsis may result in dysfunction of innate and adaptive immune system, including the abnormal disorder of immune response of T lymphocytes, regulatory T lymphocytes, and dendritic cells, resulting in a state of immune depression. It is of great significance that dynamic monitoring of immune function and the related indicators might help to assess the risk of secondary infection, the prognosis of septic patients, and to guide the treatment of severe sepsis.
由烧伤、创伤和手术应激引起的脓毒症,仍然是重症监护病房患者死亡的主要原因。越来越多的证据表明,脓毒症可能导致先天性和适应性免疫系统功能障碍,包括T淋巴细胞、调节性T淋巴细胞和树突状细胞免疫反应的异常紊乱,从而导致免疫抑制状态。动态监测免疫功能及相关指标,对于评估继发感染风险、脓毒症患者的预后以及指导严重脓毒症的治疗具有重要意义。