Tao En-Fu, Yuan Tian-Ming
Department of Neonatology, Children′s Hospital of Zhejiang University, Hangzhou 310003, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Feb;18(2):177-82. doi: 10.7499/j.issn.1008-8830.2016.02.015.
Vitamin A is a fat-soluble vitamin, and it is not only necessary for the normal growth and development of epithelial cells, but also plays a very important role in the normal growth and development of the retina, lungs, gastrointestinal tract, brain, and immune system. Studies have confirmed that the low level of vitamin A in premature infants at birth can last through the entire infancy. Recently, there have been particular concerns about the level of vitamin A and development of diseases in premature infants, with major focuses on the related mechanisms of action of vitamin A in respiratory distress syndrome, chronic lung disease, retinopathy of prematurity, necrotizing enterocolitis, patent ductus arteriosus, and infections in premature infants, which still awaits further investigation.This paper summarizes and analyzes the current status of research on vitamin A level and diseases of premature infants at home and abroad. In addition, although enough evidence suggests that vitamin A supplementation is beneficial to preterm infants, evidence is still lacking for recommended methods for supplementation and dose of vitamin A, and further studies are needed.
维生素A是一种脂溶性维生素,它不仅是上皮细胞正常生长发育所必需的,而且在视网膜、肺、胃肠道、大脑和免疫系统的正常生长发育中也起着非常重要的作用。研究证实,早产儿出生时维生素A水平较低的情况会持续整个婴儿期。最近,人们特别关注早产儿维生素A水平与疾病发生情况,主要集中在维生素A在呼吸窘迫综合征、慢性肺病、早产儿视网膜病变、坏死性小肠结肠炎、动脉导管未闭以及早产儿感染中的相关作用机制,这些仍有待进一步研究。本文总结并分析了国内外关于早产儿维生素A水平与疾病的研究现状。此外,尽管有足够的证据表明补充维生素A对早产儿有益,但在维生素A的推荐补充方法和剂量方面仍缺乏证据,需要进一步研究。