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急性运动轴索性神经病患者出现意外快速改善及神经源性心肌顿抑:一例报告及文献综述

Unexpected Rapid Improvement and Neurogenic Stunned Myocardium in a Patient With Acute Motor Axonal Neuropathy: A Case Report and Literature Review.

作者信息

Magid-Bernstein Jessica, Al-Mufti Fawaz, Merkler Alexander E, Roh David, Patel Sweta, May Teresa L, Agarwal Sachin, Claassen Jan, Park Soojin

机构信息

Department of Neurology, Columbia University Medical Center, New York, NY.

出版信息

J Clin Neuromuscul Dis. 2016 Mar;17(3):135-41. doi: 10.1097/CND.0000000000000109.

Abstract

Acute Motor Axonal Neuropathy-type Guillain-Barré Syndrome (GBS) is a subset of GBS with either a rapidly improving or protracted course that was first described in China. We describe a 27-year-old previously healthy woman with weakness that progressed to complete tetraplegia and areflexia within 2 weeks after an upper respiratory illness. A lumbar puncture performed 4 days after onset of neurologic symptoms was inconclusive for GBS, and electromyography revealed complete motor axonal neuropathy. The patient had Mycoplasma pneumoniae in her nares and blood, and several antiganglioside antibodies in her blood. She was treated with plasmapheresis, antibiotics, and physical therapy. Her motor function and reflexes improved rapidly with treatment, and she was able to ambulate within 3 weeks. She also experienced cardiomyopathy, which improved with plasmapheresis. We report a rare case of Mycoplasma pneumonia-associated acute motor axonal neuropathy-type GBS presenting with complete tetraplegia, areflexia, and neurogenic stunned myocardium that rapidly improved with plasmapheresis.

摘要

急性运动轴索性神经病型吉兰-巴雷综合征(GBS)是GBS的一个亚型,其病程呈快速改善或迁延,最初在中国被描述。我们报告一名27岁既往健康的女性,在上呼吸道感染后2周内出现肌无力,并进展为完全性四肢瘫和无反射。神经系统症状出现4天后进行的腰椎穿刺对GBS诊断不明确,肌电图显示为完全性运动轴索性神经病。该患者鼻腔和血液中检测到肺炎支原体,血液中存在多种抗神经节苷脂抗体。她接受了血浆置换、抗生素治疗和物理治疗。治疗后其运动功能和反射迅速改善,3周内能够行走。她还出现了心肌病,血浆置换后病情好转。我们报告了一例罕见的肺炎支原体相关急性运动轴索性神经病型GBS,表现为完全性四肢瘫、无反射和神经源性 stunned 心肌,经血浆置换后迅速改善。 (注:“neurogenic stunned myocardium”中“stunned”直译为“惊愕的、受惊吓的”,这里结合语境意译为“stunned心肌”,可能是医学上一种特定表述,具体准确含义需结合医学专业知识进一步确定 )

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