麦加地区新型公式的介绍以及既往红细胞指数和公式在鉴别β地中海贫血特征与缺铁性贫血中的评估
Introduction of new formulas and evaluation of the previous red blood cell indices and formulas in the differentiation between beta thalassemia trait and iron deficiency anemia in the Makkah region.
作者信息
Zaghloul Amal, Al-Bukhari T A M A, Bajuaifer Nada, Shalaby Maged, Al-Pakistani H A, Halawani Saeed H, Teama Shirin H, Wassif Ghada A
机构信息
a Department of Hematology and Immunology, Faculty of Medicine , Umm Al-Qura University , Makkah , Saudi Arabia.
c Department of Clinical Pathology, Faculty of Medicine , Ain Shams University , Cairo , Egypt.
出版信息
Hematology. 2016 Jul;21(6):351-8. doi: 10.1080/10245332.2015.1133753. Epub 2016 Mar 1.
BACKGROUND
Many formulas from red blood cell (RCB) indices are instructed to differentiate between iron deficiency anemia (IDA) and beta thalassemia trait. None had 100% Youden index.
AIM OF THE WORK
To introduce two new formulas and evaluate them in the differentiation between IDA and beta thalassemia trait in adults Saudi (male and female; male; female) in the Makkah region. Furthermore, to evaluate the previous formulas in our population.
METHODS
A total of 249 participants, 91 with IDA, 123 with beta thalassemia trait, and 35 healthy persons. All subjected to complete blood count, measurement of iron profile, hemoglobin electrophoresis and hemoglobin A2 by column chromatography. The first new formula equal hemoglobin (Hb) + hematocrit (Hct) + RBC and second equals Hb + Hct + RBC-red cell distribution (RDW). The previous formula used is England and Fraser, Mentzer, Strivastava, Ehsani, Green and King, red cell distribution index, Ricerca, and Shine and Lal Results: In both men and women, the England and Fraser was the best with a Youden's index of 70.4%, followed by Green and King 67.4%. In men, the England and Fraser and our new formula 1 had the highest Youden' index 84.7% and 84.1%, respectively. In women, the England and Fraser and RDW index had the highest Youden' index 74% and 69.2%, respectively.
CONCLUSION
The England and Fraser and our new formula 1 are the best formulas in men. The England and Fraser and RDW index are the best formulas in women.
背景
许多红细胞（RCB）指数公式被用于鉴别缺铁性贫血（IDA）和β地中海贫血特征。但没有一个公式的约登指数为100%。
研究目的
引入两个新公式，并在麦加地区的沙特成年人（男性和女性、男性、女性）中评估它们在鉴别IDA和β地中海贫血特征方面的性能。此外，评估我们人群中之前的公式。
方法
共有249名参与者，91名患有IDA，123名有β地中海贫血特征，35名健康人。所有人都进行了全血细胞计数、铁代谢指标测定、血红蛋白电泳以及通过柱色谱法测定血红蛋白A2。第一个新公式为血红蛋白（Hb）+血细胞比容（Hct）+红细胞计数（RBC），第二个新公式为Hb + Hct + RBC - 红细胞分布宽度（RDW）。使用的之前的公式有英格兰和弗雷泽公式、门泽尔公式、斯特里瓦斯塔瓦公式、埃萨尼公式、格林和金公式、红细胞分布指数公式、里塞尔卡公式以及沙恩和拉尔公式。结果：在男性和女性中，英格兰和弗雷泽公式的表现最佳，约登指数为70.4%，其次是格林和金公式，为67.4%。在男性中，英格兰和弗雷泽公式以及我们的新公式1的约登指数最高，分别为84.7%和84.1%。在女性中，英格兰和弗雷泽公式以及RDW指数的约登指数最高，分别为74%和69.2%。
结论
英格兰和弗雷泽公式以及我们的新公式1是男性中最佳的公式。英格兰和弗雷泽公式以及RDW指数是女性中最佳的公式。
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