Hoefeler H, Duran I, Hechmati G, Garzon Rodriguez C, Lüftner D, Ashcroft J, Bahl A, Atchison C, Wei R, Thomas E, Lorusso V
Forschungsszentrum-ruhr, KliFoCenter GmbH, Pferdebachstr. 30, 58455 Witten, Germany.
Hospital Universitario Virgen del Rocio, Avda. Manuel Siurot s/n, 41013 Seville, Spain; Centro Integral Oncologico Clara Campal (CIOCC), Calle Ona 10, 28050 Madrid, Spain.
J Bone Oncol. 2014 May 9;3(2):40-8. doi: 10.1016/j.jbo.2014.04.001. eCollection 2014 May.
Skeletal-related events (SREs; pathologic fracture, radiation or surgery to bone, spinal cord compression) frequently occur in patients with advanced cancer with bone metastases/lesions. Limited data on the associated patient and economic burden are available to aid in resource planning and evaluating treatment options.
Patients with bone metastases/lesions secondary to breast, lung or prostate cancer or multiple myeloma; with at least one SRE within 97 days prior to enrollment; life expectancy of at least 6 months; and Eastern Cooperative Oncology Group performance status 0, 1 or 2 were recruited. Information on health resource utilization (HRU; including number/duration of hospitalizations, outpatient visits, procedures), attributed by investigators to be associated with a SRE, was collected retrospectively for up to 97 days prior to enrollment and prospectively for up to 18-21 months.
A total of 631 patients contributing 1282 SREs, were enrolled across Germany, Italy, Spain and the United Kingdom. Approximately a third of all SREs required an inpatient stay. Mean duration of inpatient stay for patients with SREs requiring one ranged from 8.4 to 41.1 days across all countries and SRE types.
All types of SREs are associated with substantial HRU burden. Preventing SREs by using the best therapeutic options available may help to reduce the burden to patients and healthcare systems.
骨相关事件（SREs；病理性骨折、骨放疗或手术、脊髓压迫）在伴有骨转移/骨病变的晚期癌症患者中频繁发生。关于相关患者负担和经济负担的可用数据有限，难以用于资源规划和评估治疗方案。
招募继发于乳腺癌、肺癌、前列腺癌或多发性骨髓瘤且伴有骨转移/骨病变的患者；入组前97天内至少发生一次SRE；预期寿命至少6个月；东部肿瘤协作组体能状态为0、1或2。回顾性收集入组前长达97天以及前瞻性收集长达18 - 21个月的、研究者认为与SRE相关的健康资源利用（HRU；包括住院次数/时长、门诊就诊、手术）信息。
德国、意大利、西班牙和英国共入组631例患者，发生1282次SRE。所有SRE中约三分之一需要住院治疗。在所有国家和SRE类型中，因SRE需要住院的患者平均住院时长为8.4至41.1天。
所有类型的SRE均与巨大的HRU负担相关。采用最佳可用治疗方案预防SRE可能有助于减轻患者和医疗系统的负担。
