[荧光原位杂交检测117例多发性骨髓瘤患者的细胞遗传学异常及预后]
[Cytogenetic Abnormalities and Outcomes of 117 Patients with Multiple Myeloma Detected by FISH].
作者信息
Zhai Bing, Zou Dan-Dan, Yan Jian-Jun, Wang Nan, Wang Li-Li, Zhu Hong-Li, Huang Wen-Rong, Yu Li
机构信息
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China.
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Feb;24(1):127-30. doi: 10.7534/j.issn.1009-2137.2016.01.025.
OBJECTIVE
To analyze the cytogenetic abnormalities and prognostic outcomes of patients with multiple myeloma (MM) detected by fluorescence in situ hybridization (FISH).
METHODS
The clinical record of 117 newly-diagnosed patients with MM treated in department of hematology and geriatric hematology of our hospital for 7 years were collected, and their molecular cytogenetic abnormalities detected by FISH and the clinical outcome were analyzed retrospectively.
RESULTS
The detected rate of cytogenetic abnormality was 76.9%(90/117), the most common abnormality deteted by FISH was 1q21+ (71.1%), followed by 13q- (56.6%). The cross comparison method showed that 13q- and 17p13-, t(11;14) and t(4;14) were related respectively. All the patients with cytogenetic abnormalities showed no significant difference in the overall survival from cytogenetic normal patients.
CONCLUSION
The positive rate of molecular cytogenetic abnormalities detected by FISH in MM patients is high, but data from larger and longer studies are needed to evaluate the prognostic outcomes.
目的
分析采用荧光原位杂交（FISH）检测的多发性骨髓瘤（MM）患者的细胞遗传学异常及预后情况。
方法
收集我院血液科及老年血液科7年间收治的117例初诊MM患者的临床记录，回顾性分析其FISH检测的分子细胞遗传学异常及临床结局。
结果
细胞遗传学异常检出率为76.9%（90/117），FISH检测最常见的异常为1q21+（71.1%），其次为13q-（56.6%）。交叉比较法显示，13q-与17p13-、t(11;14)与t(4;14)分别相关。所有细胞遗传学异常患者与细胞遗传学正常患者的总生存期无显著差异。
结论
MM患者中FISH检测的分子细胞遗传学异常阳性率较高，但需要来自更大规模和更长时间研究的数据来评估预后情况。
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