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双侧胸锁乳突肌注射肉毒杆菌毒素治疗难治性前斜颈。

Bilateral Lower Sternocleidomastoid Botulinum Toxin Injections to Address Refractory Anterocollis.

作者信息

Peng-Chen Zhongxing, Thompson Amanda, Rodriguez Ramon L

机构信息

*Department of Neurology, Center for Movement Disorders & Neurorestoration, Gainesville, FL †ATIX Foundation ‡Faculty of Medicine, University for Development, Las Condes, Santiago, Chile.

出版信息

Neurologist. 2016 Mar;21(2):30-1. doi: 10.1097/NRL.0000000000000072.

Abstract

Anterocollis is a type of cervical dystonia characterized by simultaneous and repetitive antagonist muscles contractions, resulting in abnormal neck flexion. It was described with a frequency of 6.8% from 399 patients with diagnosis of cervical dystonia and usually coexists with torticollis and/or laterocollis, as mixed cervical dystonia patterns. Botulinum toxin is usually a practical and effective treatment for cervical dystonia. The target muscles to inject in anterocollis are usually sternocleidomastoid and scalene muscles. There is also a case report suggesting longus collis involvement. Nevertheless, the dosage of the medication in anterocollis is limited by frequent side effects of dysphagia. We described 2 cases of refractory anterocollis. They did not benefit from conventional bilateral upper portion of sternocleidomastoid muscle injections with OnabotulinumtoxinA, but notably improved their symptoms and clinical global impression after switching to injections into bilateral lower portion of sternocleidomastoid muscles, without significant side effects.

摘要

前斜颈是一种颈部肌张力障碍,其特征为拮抗肌同时反复收缩,导致颈部异常前屈。在399例诊断为颈部肌张力障碍的患者中,其发生率为6.8%,通常与斜颈和/或侧斜颈同时存在,属于混合型颈部肌张力障碍模式。肉毒杆菌毒素通常是治疗颈部肌张力障碍的一种实用且有效的方法。前斜颈的注射靶肌通常是胸锁乳突肌和斜角肌。也有病例报告提示颈长肌受累。然而,前斜颈的药物剂量受吞咽困难等频繁副作用的限制。我们描述了2例难治性前斜颈病例。他们接受常规双侧胸锁乳突肌上部注射A型肉毒毒素未获益处,但改用双侧胸锁乳突肌下部注射后症状显著改善,临床整体印象良好,且无明显副作用。

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