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[特异性免疫疗法对变应性鼻炎患者的短期疗效及影响因素]

[Short-term efficacy and factors of specific immunotherapy on patients with allergic rhinitis].

作者信息

Geng Congli, Yuan Xiaopei, Xing Zhimin, Yu Lisheng, Wang Min, Lin Yuqiang, Liu Yan, Zhang Gai

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Nov;29(21):1857-9, 1863.

Abstract

OBJECTIVE

To evaluate the short-term efficacy and investigate the factors of specific immunotherapy (SIT) efficacy of allergic rhinitis.

METHOD

Fifty-seven patients with allergic rhinitis to dermatophagoides pteronysinus were included to receive SIT. Pair t-test was used to compare the symptom scores, visual analogue scores (VAS) and medication scores in patients before SIT and into maintain treatment statement to evaluate the clinical efficacy. T-test and Spearman correlation analysis were used to analyze the correlation between gender, age,reaction condition of skin prick test (SPT) and serum sIgE and the efficacy of SIT.

RESULT

SIT was able to significantly reduce the symptom scores, VAS and medication scores. But the correlation between gender, age, SPT, and sIgE and theefficacy of SIT were not significant.

CONCLUSION

SIT is effective in the short-term treatment of AR. Further research is needed to investigate the factors that impact the efficacy of SIT.

摘要

目的

评估特异性免疫疗法(SIT)治疗变应性鼻炎的短期疗效,并探究其疗效的影响因素。

方法

纳入57例对尘螨过敏的变应性鼻炎患者接受SIT治疗。采用配对t检验比较患者SIT治疗前及维持治疗阶段的症状评分、视觉模拟评分(VAS)和用药评分,以评估临床疗效。采用t检验和Spearman相关分析,分析性别、年龄、皮肤点刺试验(SPT)反应情况及血清特异性免疫球蛋白E(sIgE)与SIT疗效之间的相关性。

结果

SIT能够显著降低症状评分、VAS评分和用药评分。但性别、年龄、SPT及sIgE与SIT疗效之间的相关性不显著。

结论

SIT在变应性鼻炎的短期治疗中有效。需要进一步研究以探究影响SIT疗效的因素。

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