与原发性和获得性免疫缺陷相关的B细胞淋巴增殖性疾病

B-cell Lymphoproliferative Disorders Associated with Primary and Acquired Immunodeficiency.

作者信息

Low Lawrence K, Song Joo Y

机构信息

Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.

出版信息

Surg Pathol Clin. 2016 Mar;9(1):55-77. doi: 10.1016/j.path.2015.10.003.

DOI:10.1016/j.path.2015.10.003

PMID:26940268

Abstract

The diagnosis of lymphoproliferative disorders associated with immunodeficiency can be challenging because many of these conditions have overlapping clinical and pathologic features and share similarities with their counterparts in the immunocompetent setting. There are subtle but important differences between these conditions that are important to recognize for prognostic and therapeutic purposes. This article provides a clinicopathologic update on how understanding of these B-cell lymphoproliferations in immunodeficiency has evolved over the past decade.

摘要

免疫缺陷相关淋巴增殖性疾病的诊断颇具挑战性，因为其中许多病症具有重叠的临床和病理特征，且与免疫功能正常情况下的同类病症存在相似之处。这些病症之间存在细微但重要的差异，为了预后和治疗目的，识别这些差异非常重要。本文提供了一份临床病理更新内容，介绍了在过去十年中，我们对免疫缺陷状态下这些B细胞淋巴增殖性疾病的认识是如何演变的。