富含亮氨酸重复序列激酶2是B细胞功能的调节因子，影响内环境稳态、BCR信号传导、IgA产生和TI抗原反应。
Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses.
作者信息
Kubo Makoto, Nagashima Ryuichi, Ohta Etsuro, Maekawa Tatsunori, Isobe Yumiko, Kurihara Mitsue, Eshima Koji, Iwabuchi Kazuya, Sasaoka Toshikuni, Azuma Sadahiro, Melrose Heather L, Farrer Matthew J, Obata Fumiya
机构信息
Division of Immunology, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan; Division of Clinical Immunology, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan; Research Facility of Regenerative Medicine and Cell Design, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
Division of Clinical Immunology, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
出版信息
J Neuroimmunol. 2016 Mar 15;292:1-8. doi: 10.1016/j.jneuroim.2016.01.005. Epub 2016 Jan 8.
LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRK2 mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRK2-knockout (LRRK2(-/-)) mice. LRRK2(-/-) mice had significantly higher counts of peritoneal B1 cells than wild-type mice. After BCR stimulation, phosphor-Erk1/2 of splenic B2 cells was enhanced to a higher degree in LRRK2(-/-) mice. LRRK2(-/-) mice had a significantly higher serum IgA level, and TNP-Ficoll immunization increased the titer of serum anti-TNP IgM antibody. LRRK2 may play important roles in B cells.
LRRK2是常染色体显性遗传性帕金森病的致病分子。B2细胞表达的LRRK2 mRNA水平比B1细胞高得多。为了揭示LRRK2在B细胞中的功能，我们分析了LRRK2基因敲除（LRRK2(-/-)）小鼠的B细胞功能。LRRK2(-/-)小鼠腹腔B1细胞的数量显著高于野生型小鼠。在B细胞受体（BCR）刺激后，LRRK2(-/-)小鼠脾脏B2细胞中磷酸化的细胞外信号调节激酶1/2（phosphor-Erk1/2）增强程度更高。LRRK2(-/-)小鼠血清IgA水平显著更高，并且三硝基苯-菲可（TNP-Ficoll）免疫增加了血清抗TNP IgM抗体的滴度。LRRK2可能在B细胞中发挥重要作用。
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