SOX7通过对Wnt/β-连环蛋白信号通路的HMG盒依赖性调控与人类胶质瘤的抑制相关。
SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling.
作者信息
Zhao Tianshu, Yang Hui, Tian Yu, Xie Qing, Lu Yun, Wang Yu, Su Ning, Dong Baijing, Liu Xian, Wang Ce, Jiang Chuanlu, Liu Xiaoqian
机构信息
Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
出版信息
Cancer Lett. 2016 May 28;375(1):100-107. doi: 10.1016/j.canlet.2016.02.044. Epub 2016 Mar 2.
SOX7 has been recently recognized as a tumor suppressor belonging to the SOX (SRY-related HMG-box) family of a transcription factor. However, its role in human gliomas is unknown. Our study showed that SOX7 expression was significantly downregulated in human gliomas. Statistical analysis showed that SOX7 suppression was associated with higher histological grades of tumors in glioma tissues. SOX7 could suppress tumor properties both in vivo and in vitro, and depletion of the HMG domain abolishes its tumor suppressive roles. In vitro assays demonstrated that SOX7 could downregulate Wnt/β-catenin transcription and decrease the expression of Cyclin D1 and c-Myc, while the mutant SOX7 lost these functions. These results suggested that the HMG-box is a key domain of SOX7 for negatively regulating the Wnt/β-catenin signaling pathway when functioning as a tumor suppressor in a glioma.
SOX7最近被认为是一种肿瘤抑制因子，属于转录因子的SOX（SRY相关HMG盒）家族。然而，其在人类胶质瘤中的作用尚不清楚。我们的研究表明，SOX7在人类胶质瘤中表达明显下调。统计分析表明，SOX7抑制与胶质瘤组织中肿瘤的较高组织学分级相关。SOX7在体内和体外均可抑制肿瘤特性，HMG结构域的缺失消除了其肿瘤抑制作用。体外实验表明，SOX7可下调Wnt/β-连环蛋白转录，并降低细胞周期蛋白D1和c-Myc的表达，而突变型SOX7则失去了这些功能。这些结果表明，当SOX7在胶质瘤中作为肿瘤抑制因子发挥作用时，HMG盒是其负调控Wnt/β-连环蛋白信号通路的关键结构域。
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