Ashkenazi A, Peralta E G, Winslow J W, Ramachandran J, Capon D J
Trends Pharmacol Sci. 1989 Dec;Suppl:16-22.
The regulation of cellular signal transduction and growth by four human muscarinic acetylcholine receptor (mAChR) subtypes has been studied comparatively. The four mAChRs fall into two functional sub-groups, based on their primary effects on second messenger formation; two of the receptors strongly inhibit adenylyl cyclase activity, whereas the other two strongly stimulate PI hydrolysis. Studies on mAChR regulation of two cellular events involved in cellular growth regulation, the transcription of proto-oncogene c-fos and DNA synthesis, indicate that these events are efficiently activated by those mAChRs which couple primarily to phospholipase C.
对四种人类毒蕈碱型乙酰胆碱受体（mAChR）亚型在细胞信号转导和生长方面的调节作用进行了比较研究。基于它们对第二信使形成的主要影响，这四种mAChR可分为两个功能亚组；其中两种受体强烈抑制腺苷酸环化酶活性，而另外两种则强烈刺激磷脂酰肌醇水解。对参与细胞生长调节的两个细胞事件，即原癌基因c-fos的转录和DNA合成的mAChR调节研究表明，这些事件可被主要与磷脂酶C偶联的那些mAChR有效激活。
