膝关节软骨缺损的自体软骨细胞移植（ACI）：德国骨科与创伤学会（DGOU）“临床组织再生”工作组指南
Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU).
作者信息
Niemeyer P, Albrecht D, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Bosch U, Erggelet C, Fickert S, Gebhard H, Gelse K, Günther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen N M, Müller P E, Nöth U, Petersen J P, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs M R, Welsch G H, Zinser W, Fritz J
机构信息
Department Orthopädie und Traumatologie, Universitätsklinikum Freiburg, Germany.
Klinik im Kronprinzenbau, Reutlingen, Germany.
出版信息
Knee. 2016 Jun;23(3):426-35. doi: 10.1016/j.knee.2016.02.001. Epub 2016 Mar 3.
BACKGROUND
Autologous chondrocyte implantation (ACI) is an established and well-accepted procedure for the treatment of localised full-thickness cartilage defects of the knee.
METHODS
The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) describes the biology and function of healthy articular cartilage, the present state of knowledge concerning therapeutic consequences of primary cartilage lesions and the suitable indication for ACI.
RESULTS
Based on best available scientific evidence, an indication for ACI is given for symptomatic cartilage defects starting from defect sizes of more than three to four square centimetres; in the case of young and active sports patients at 2.5cm(2), while advanced degenerative joint disease needs to be considered as the most important contraindication.
CONCLUSION
The present review gives a concise overview on important scientific background and the results of clinical studies and discusses the advantages and disadvantages of ACI.
LEVEL OF EVIDENCE
Non-systematic Review.
背景
自体软骨细胞移植（ACI）是一种成熟且被广泛接受的治疗膝关节局限性全层软骨缺损的方法。
方法
德国骨科与创伤学会（DGOU）“临床组织再生”工作组的本综述描述了健康关节软骨的生物学和功能、原发性软骨损伤治疗后果的现有知识状态以及ACI的合适适应症。
结果
基于现有最佳科学证据，对于面积超过三到四平方厘米的有症状软骨缺损，给出了ACI的适应症；对于年轻且活跃的运动患者，缺损面积为2.5平方厘米时适用，而晚期退行性关节病应被视为最重要的禁忌症。
结论
本综述简要概述了重要的科学背景和临床研究结果，并讨论了ACI的优缺点。
证据水平
非系统性综述。
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