Lusinchi A, Luboinski B, Wibault P, Dube P, Janot F, Vericel R, Eschwege F
Institut Gustave-Roussy, Villejuif.
Ann Otolaryngol Chir Cervicofac. 1989;106(8):577-82.
197 patients, with an early glottic cancer, were heated with radiotherapy at the Institute Gustave Roussy, between 1970 and 1983. Radiation was delivered up to a dose of 65 Gy over 6 1/2 weeks on a small area centered on the glottic region. All patients had previously undergone direct laryngoscopy and showed T1 stage tumours (175 T1a and 22 T1b) although in 32 cases there was a suspicion of very limited involvement of the ventricle or sub-glottis. 5 year survival for the overall population was 77.5%. 38 local recurrences were observed, 1/4 of these occurring after 3 years. For the overall population, local control at 5 years was 85.7%. Suspicion of supra or sub-glottic involvement and the presence of impaired mobility of the larynx were shown to be important prognostic factors. Local control at 5 years was 90% for "true T1" cases. Few complications were observed and the functional results of irradiation were judged to be excellent.
1970年至1983年间，古斯塔夫·鲁西研究所对197例早期声门癌患者进行了放射治疗。在以声门区域为中心的小区域内，6个半月内给予65 Gy的辐射剂量。所有患者此前均接受了直接喉镜检查，显示为T1期肿瘤（175例T1a和22例T1b），不过在32例病例中，怀疑有非常有限的室或声门下受累。总体人群的5年生存率为77.5%。观察到38例局部复发，其中1/4发生在3年后。总体人群5年的局部控制率为85.7%。声门上或声门下受累的怀疑以及喉部活动度受损被证明是重要的预后因素。“真正的T1”病例5年的局部控制率为90%。观察到的并发症很少，放疗的功能结果被判定为极佳。
