铁促进的末端炔烃的氯苯甲醚化反应：通过苄位 C(sp(3))-H 键功能化实现。
Fe-Promoted Chlorobenzylation of Terminal Alkynes through Benzylic C(sp(3))-H Bond Functionalization.
机构信息
College of Chemistry and Material Chemistry, Sichuan Normal University , Sichuan 610066, China.
Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University , Beijing 100871, China.
出版信息
Org Lett. 2016 Mar 18;18(6):1238-41. doi: 10.1021/acs.orglett.5b02472. Epub 2016 Mar 7.
A chlorobenzylation of terminal alkynes through Fe(II)-promoted benzylic C(sp(3))-H bond functionalization in the presence of NCS as a chloride source was developed. Compared with previous methods to prepare polysubstituted alkenyl halides, the presented procedure provides an efficient alternative with high atom and step economy under mild conditions. The transformation was established to proceed through a single-electron transfer (SET) process with benzyl cations as key intermediates.
通过 Fe(II)促进的苄基 C(sp(3))-H 键功能化，在 NCS 作为氯源的存在下，实现了末端炔烃的氯苯甲醚化。与以前制备多取代烯基卤化物的方法相比，该方法在温和条件下具有高效、原子经济性和步骤经济性高的优点。该转化通过单电子转移（SET）过程进行，苄基阳离子作为关键中间体。
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