Cai Zhenzhen, Jia Renyong
Bing Du Xue Bao. 2015 Nov;31(6):704-11.
Since Epstein Barr virus was shown to encode microRNAs(miRNAs) in 2004, more than 470 miRNAs have been discovered in α-, β-, and γ-herpesviruses. MiRNAs are small non-coding RNA molecules and generally only have 18-25 nucleotides in length, which can regulate the expression of target genes by targeting its transcripts. Herpesvirus-encoded miRNAs not only target the key genes from latency to lytic replication, but also regulate various host cellular genes. Current data manifest that herpesvirus-encoded miRNAs can regulate viral latent infection and lytic replication, immune recognition, apoptosis, and tumorigenesis. The purpose of this paper is to summarize the targets and their fuction of hepesvirus-encoded miRNAs, in order to provide theoretical support for further analysis herpesviral pathogenesis.
自2004年发现爱泼斯坦-巴尔病毒可编码微小RNA（miRNA）以来，在α、β和γ疱疹病毒中已发现470多种miRNA。miRNA是小的非编码RNA分子，长度一般只有18-25个核苷酸，可通过靶向其转录本来调节靶基因的表达。疱疹病毒编码的miRNA不仅靶向从潜伏到裂解复制的关键基因，还调节各种宿主细胞基因。目前的数据表明，疱疹病毒编码的miRNA可调节病毒潜伏感染和裂解复制、免疫识别、细胞凋亡和肿瘤发生。本文旨在总结疱疹病毒编码的miRNA的靶标及其功能，为进一步分析疱疹病毒发病机制提供理论支持。
