玫瑰痤疮患者患抑郁症和焦虑症的风险增加：一项丹麦全国队列研究。

Patients with Rosacea Have Increased Risk of Depression and Anxiety Disorders: A Danish Nationwide Cohort Study.

作者信息

Egeberg Alexander, Hansen Peter Riis, Gislason Gunnar Hilmar, Thyssen Jacob Pontoppidan

机构信息

National Allergy Research Centre, Department of Dermato-Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

出版信息

Dermatology. 2016;232(2):208-13. doi: 10.1159/000444082. Epub 2016 Mar 9.

DOI:10.1159/000444082

PMID:26954304

Abstract

BACKGROUND

Rosacea is a chronic skin condition that affects self-esteem and quality of life. However, data on depression and anxiety in patients with rosacea are scarce.

OBJECTIVE

The aim of this study was to investigate the relationship between rosacea and new-onset depression and anxiety disorders.

METHODS

Data on all Danish citizens aged ≥18 years between January 1, 1997, and December 31, 2011, were linked at individual level in nationwide registers. Incidence rates per 1,000 person-years were calculated, and crude and adjusted incidence rate ratios (IRRs) with 95% confidence intervals (95% CIs) were estimated by Poisson regression models.

RESULTS

The study comprised a total of 4,632,341 individuals, including 30,725 and 24,712 patients with mild and moderate-to-severe rosacea, respectively. Mild and moderate-to-severe rosacea increased the risk of both depression [IRR 1.89 (95% CI 1.82-1.96) and IRR 2.04 (95% CI 1.96-2.12)] and anxiety disorders [IRR 1.80 (95% CI 1.75-1.86) and IRR 1.98 (95% CI 1.91-2.05)].

CONCLUSIONS

Rosacea was associated with a disease severity-dependent, increased risk of depression and anxiety disorders. The findings may call for increased awareness of psychiatric morbidity in patients with rosacea.

摘要

背景

酒渣鼻是一种影响自尊和生活质量的慢性皮肤病。然而，关于酒渣鼻患者抑郁和焦虑的数据却很少。

目的

本研究旨在调查酒渣鼻与新发抑郁和焦虑症之间的关系。

方法

1997年1月1日至2011年12月31日期间所有年龄≥18岁的丹麦公民的数据在全国登记册中按个体水平进行关联。计算每1000人年的发病率，并通过泊松回归模型估计粗发病率和调整发病率比（IRR）及其95%置信区间（95%CI）。

结果

该研究共纳入4632341人，其中轻度酒渣鼻患者30725人，中度至重度酒渣鼻患者24712人。轻度和中度至重度酒渣鼻均增加了抑郁[IRR 1.89（95%CI 1.82 - 1.96）和IRR 2.04（95%CI 1.96 - 2.12）]和焦虑症[IRR 1.80（95%CI 1.75 - 1.86）和IRR 1.98（95%CI 1.91 - 2.05）]的风险。