State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
Cell Metab. 2016 Mar 8;23(3):399-401. doi: 10.1016/j.cmet.2016.02.017.
AMPK senses decreased cellular energy levels, triggering mitochondrial autophagy or mitophagy through activating ULK1 and inhibiting mTORC1. In a recent report, Toyama et al. (2016) show that activated AMPK phosphorylation of MFF is critical for mitochondrial fission. Unphosphorylatable MFF mutants block mitophagy, connecting AMPK to mitochondrial fission and to mitophagy.
AMPK 感知到细胞能量水平下降，通过激活 ULK1 和抑制 mTORC1 来触发线粒体自噬或 mitophagy。在最近的一份报告中，Toyama 等人（2016 年）表明，激活的 AMPK 对 MFF 的磷酸化对于线粒体裂变至关重要。不可磷酸化的 MFF 突变体阻断了 mitophagy，将 AMPK 与线粒体裂变和 mitophagy 联系起来。
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