Vollmer Jannik, Fried Patrick, Sánchez-Aragón Max, Lopes Carla S, Casares Fernando, Iber Dagmar
Department of Biosystems, Science and Engineering (D-BSSE), ETH Zurich, Mattenstraße 26, Basel 4058, Switzerland Swiss Institute of Bioinformatics (SIB), Mattenstraße 26, Basel 4058, Switzerland.
Department of Gene Regulation and Morphogenesis, CABD, CSIC and Universidad Pablo de Olavide, Campus UPO, Seville 41013, Spain.
Development. 2016 May 1;143(9):1482-90. doi: 10.1242/dev.129775. Epub 2016 Mar 10.
The size and shape of organs is species specific, and even in species in which organ size is strongly influenced by environmental cues, such as nutrition or temperature, it follows defined rules. Therefore, mechanisms must exist to ensure a tight control of organ size within a given species, while being flexible enough to allow for the evolution of different organ sizes in different species. We combined computational modeling and quantitative measurements to analyze growth control in the Drosophila eye disc. We find that the area growth rate declines inversely proportional to the increasing total eye disc area. We identify two growth laws that are consistent with the growth data and that would explain the extraordinary robustness and evolutionary plasticity of the growth process and thus of the final adult eye size. These two growth laws correspond to very different control mechanisms and we discuss how each of these laws constrains the set of candidate biological mechanisms for growth control in the Drosophila eye disc.
器官的大小和形状具有物种特异性，即使在那些器官大小受环境线索（如营养或温度）强烈影响的物种中，其生长也遵循特定的规则。因此，必然存在一些机制来确保在特定物种内严格控制器官大小，同时又足够灵活，以允许不同物种进化出不同的器官大小。我们结合计算建模和定量测量来分析果蝇眼盘的生长控制。我们发现，面积增长率与眼盘总面积的增加成反比下降。我们确定了两条与生长数据一致的生长规律，这两条规律可以解释生长过程以及最终成虫眼睛大小的非凡稳健性和进化可塑性。这两条生长规律对应着非常不同的控制机制，我们将讨论每条规律如何限制果蝇眼盘生长控制的候选生物学机制。
