Medeiros Leonardo Mariano Inácio, de Castro Pollyanna Celso Felipe, Felício André C, Queiros Bárbara Bernardo, Silva Sonia Maria Cesar Azevedo, Ferraz Henrique Ballalai, Bertolucci Paulo Henrique Ferreira, Borges Vanderci
Unidade de Distúrbios do Movimento, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2016 Feb;74(2):122-7. doi: 10.1590/0004-282X20160006.
Essential tremor (ET) was long believed to be a monosymptomatic disorder. However, studies have evidenced structural changes and attention is now being focused on non-motor symptoms. The objective of the study is to describe and compare ET patients with control groups according to their cognitive functions, and secondarily, to compare their sociodemographic characteristics and other clinical features. All participants were assessed using the Fahn-Tolosa-Marin Tremor Rating Scale for the severity of tremor; a neuropsychological assessment battery and a screening questionnaire for mood and anxiety symptoms. There were no significant age and gender differences between all groups. As for neuropsychological assessment results, a significant difference was found only in the Pegboard test. We also found a significant negative correlation between a poorer cognitive test results and disease severity and a significant differences regarding depression or anxiety symptoms in patients with ET. The study results suggest that patients with ET have impaired manual dexterity and attention.
长期以来,人们一直认为特发性震颤(ET)是一种单症状疾病。然而,研究已经证明了其结构变化,现在人们的注意力正集中在非运动症状上。本研究的目的是根据认知功能描述和比较ET患者与对照组,其次,比较他们的社会人口学特征和其他临床特征。所有参与者均使用Fahn-Tolosa-Marin震颤评分量表评估震颤严重程度;使用一套神经心理学评估工具以及一份情绪和焦虑症状筛查问卷。所有组之间在年龄和性别上均无显著差异。至于神经心理学评估结果,仅在钉板测试中发现了显著差异。我们还发现认知测试结果较差与疾病严重程度之间存在显著负相关,并且ET患者在抑郁或焦虑症状方面存在显著差异。研究结果表明,ET患者的手部灵活性和注意力受损。