Bouraoui R, Bouladi M, Nefaa F, Limaiem R, El Matri L
Service B, faculté de médecine de Tunis, institut Hédi Rais d'ophtalmologie de Tunis, université Tunis El Manar, boulevard du 9-Avril-1938, Tunis, Tunisie.
Service B, faculté de médecine de Tunis, institut Hédi Rais d'ophtalmologie de Tunis, université Tunis El Manar, boulevard du 9-Avril-1938, Tunis, Tunisie.
J Fr Ophtalmol. 2016 Mar;39(3):272-6. doi: 10.1016/j.jfo.2015.10.007. Epub 2016 Mar 16.
To investigate whether spectral domain optical coherence tomography (SD-OCT) is helpful for the diagnosis and prognosis of foveal hypoplasia in patients with overt nystagmus.
A retrospective cross-sectional study was conducted in 48 patients with overt nystagmus. All patients underwent a complete ophthalmic examination including best corrected visual acuity, biomicroscopic and fundus examinations. Spectral domain optical coherence tomography was performed using 3D OCT-2000 FA PLUS Topcon, Tokyo, Japan, for the diagnosis and grading of foveal hypoplasia, using the Thomas classification, and its possible correlation with visual acuity.
Foveal hypoplasia was diagnosed in 6 patients (12.5%). The mean age of the patients was 13.2 years (10-18 years). Mean visual acuity was 1.53/10 (0.87 LogMAR). Foveal hypoplasia was associated with aniridia in 2 patients, albinism in 3 patients and keratoconus in 1 case. On SD-OCT, foveal hypoplasia was grade 4 in 4 patients and grade 3 in 2 patients. Mean visual acuity was 2.55/10 in patients with grade 3 foveal hypoplasia and 1.22/10 in patients with grade 4 foveal hypoplasia, and the difference in visual acuity between the two groups was statistically significant (P<0.001).
SD-OCT plays a double role in the diagnosis and prognosis of foveal hypoplasia in patients with nystagmus.
探讨频域光学相干断层扫描（SD - OCT）对显性眼球震颤患者黄斑发育不全的诊断及预后评估是否有帮助。
对48例显性眼球震颤患者进行回顾性横断面研究。所有患者均接受了包括最佳矫正视力、生物显微镜检查和眼底检查在内的全面眼科检查。使用日本东京拓普康公司的3D OCT - 2000 FA PLUS进行频域光学相干断层扫描，采用托马斯分类法对黄斑发育不全进行诊断和分级，并分析其与视力的可能相关性。
6例患者（12.5%）被诊断为黄斑发育不全。患者的平均年龄为13.2岁（10 - 18岁）。平均视力为1.53/10（0.87 LogMAR）。2例黄斑发育不全患者合并无虹膜，3例合并白化病，1例合并圆锥角膜。在SD - OCT上，4例患者黄斑发育不全为4级，2例为3级。黄斑发育不全3级患者的平均视力为2.55/10，4级患者为1.22/10，两组视力差异有统计学意义（P<0.001）。
SD - OCT在眼球震颤患者黄斑发育不全的诊断和预后评估中具有双重作用。
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