Suphanklang Juthathip, Santimaleeworagun Wichai, Supasyndh Ouppatham
J Med Assoc Thai. 2015 Dec;98(12):1254-7.
Serotonin syndrome is a rare but potentially fatal complication of drugs that have effects on central nervous system serotonin. It is characterized by sudden onset of altered mental status, increased neuromuscular activity, and autonomic instability.
The authors reported a case of serotonin syndrome associated with combined therapy of monoamine oxidase-B inhibitors and selective serotonin reuptake inhibitor A 77-year-old Thai man had been taking escitalopram for depression for three years. He presented with high-grade fever and confusion two days after taking rasagiline for Parkinson's disease. He also had agitation, hallucination, and behavioral change. Escitalopram and rasagiline were discontinued but his renal function worsened, turning to acute kidney injury. He was diagnosed as serotonin syndrome.
This is the first case report of serotonin syndrome due to combination of escitalopram and rasagiline used.
血清素综合征是一种由对中枢神经系统血清素产生影响的药物引起的罕见但可能致命的并发症。其特征为精神状态改变、神经肌肉活动增加和自主神经功能不稳定的突然发作。
作者报告了一例与单胺氧化酶 - B抑制剂和选择性血清素再摄取抑制剂联合治疗相关的血清素综合征病例。一名77岁的泰国男性因抑郁症服用艾司西酞普兰三年。在服用雷沙吉兰治疗帕金森病两天后，他出现高热和意识模糊。他还伴有躁动、幻觉和行为改变。艾司西酞普兰和雷沙吉兰停药，但他的肾功能恶化，转变为急性肾损伤。他被诊断为血清素综合征。
这是首例因使用艾司西酞普兰和雷沙吉兰联合用药导致血清素综合征的病例报告。
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