2型糖尿病男性患者性腺功能减退的危险因素
Risk Factors for Hypogonadism in Male Patients with Type 2 Diabetes.
作者信息
Zheng Rendong, Cao Lin, Cao Wen, Chu Xiaoqiu, Hu Yongxin, Zhang Huifeng, Xu Juan, Sun Hongping, Bao Weiping, Liu Kemian, Liu Chao
机构信息
Department of Endocrinology and Metabolism, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu 210028, China; Department of Endocrinology and Metabolism, Jiangsu Province Academy of Traditional Chinese Medicine, 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu 210028, China.
出版信息
J Diabetes Res. 2016;2016:5162167. doi: 10.1155/2016/5162167. Epub 2016 Feb 23.
BACKGROUND
Male hypogonadism is an endocrine disease characterized by low levels of serum testosterone and is closely related to the development of diabetes. The purpose of the present study was to observe the risk factors for hypogonadism in male patients with type 2 diabetes.
METHODS
A total of 213 patients with type 2 diabetes were enrolled and divided into a low total testosterone (TT) group (=75) and a normal TT group (=138). The patients' blood glucose, blood lipids, serum insulin, and sex hormones were measured. The correlations between the patients' metabolic index and sex hormone levels were analyzed.
RESULTS
Compared with the normal TT group, body mass index (BMI), fasting insulin (FINS), and HOMA insulin resistance index (HOMA-IR) levels were significantly higher, but the luteinizing hormone (LH) levels were significantly lower in the low TT group (p < 0.05). Correlation analyses found that TT was negatively correlated with BMI, waist circumference (WC), FINS, and HOMA-IR. TT was positively correlated with LH and follicle-stimulating hormone (FSH).
CONCLUSIONS
Several risk factors of diabetes associated closely with hypogonadism. BMI, metabolic syndrome (MS), HOMA-IR, and LH are independent risk factors for hypogonadism in male patients with type 2 diabetes.
背景
男性性腺功能减退是一种以内分泌疾病，其特征为血清睾酮水平低，并且与糖尿病的发生密切相关。本研究的目的是观察2型糖尿病男性患者性腺功能减退的危险因素。
方法
总共纳入213例2型糖尿病患者，并将其分为总睾酮（TT）水平低组（n = 75）和TT正常组（n = 138）。测量患者的血糖、血脂、血清胰岛素和性激素。分析患者代谢指标与性激素水平之间的相关性。
结果
与TT正常组相比，TT水平低组的体重指数（BMI）、空腹胰岛素（FINS）和稳态模型胰岛素抵抗指数（HOMA-IR）水平显著更高，但促黄体生成素（LH）水平显著更低（p < 0.05）。相关性分析发现，TT与BMI、腰围（WC）、FINS和HOMA-IR呈负相关。TT与LH和促卵泡生成素（FSH）呈正相关。
结论
糖尿病的几个危险因素与性腺功能减退密切相关。BMI、代谢综合征（MS）、HOMA-IR和LH是2型糖尿病男性患者性腺功能减退的独立危险因素。
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