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[软骨的3D生物打印:关于烧伤耳朵重建的挑战]

[3D bioprinting of cartilage: challenges concerning the reconstruction of a burned ear].

作者信息

Visscher Dafydd O, Bos Ernst J, van Zuijlen Paul P M

机构信息

VU medisch centrum, afd. Plastische, Reconstructieve en Handchirurgie, Amsterdam.

出版信息

Ned Tijdschr Geneeskd. 2015;160:A9698.

Abstract

Reconstruction of a severely maimed ear is a major challenge. The ear is highly flexible yet tough, and has a very complex three-dimensional shape. Reconstruction of a patient's burned ear is even more complex due to surrounding tissue damage. Not only does this hamper reconstruction options, it also increases the likelihood of issues when using synthetic implant materials. In such cases, rib cartilage is the preferred option, but this tissue has practical limitations too. For these reasons, tissue engineering and 3D bioprinting may have the potential to create personalized cartilage implants for burns patients. However, 3D bioprinting is a tool to facilitate the reconstruction, and not by itself the Holy Grail. The clinical application of this technique is still at a very early stage. Nevertheless, we expect that 3D bioprinting can be utilised for facial reconstruction following burns come 2020.

摘要

严重受损耳朵的重建是一项重大挑战。耳朵柔韧性强且坚韧,具有非常复杂的三维形状。由于周围组织受损,患者烧伤耳朵的重建更为复杂。这不仅限制了重建方案,还增加了使用合成植入材料时出现问题的可能性。在这种情况下,肋软骨是首选,但这种组织也有实际局限性。出于这些原因,组织工程和3D生物打印可能有潜力为烧伤患者制造个性化软骨植入物。然而,3D生物打印只是促进重建的一种工具,其本身并非万能。这项技术的临床应用仍处于非常早期的阶段。尽管如此,我们预计到2020年3D生物打印可用于烧伤后的面部重建。

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