Tiago Daniel M, Conceição Natércia, Caiado Helena, Laizé Vincent, Cancela Maria Leonor
Centre of Marine Sciences (CCMAR), University of Algarve, Faro, Portugal.
Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal.
FEBS Lett. 2016 Apr;590(8):1234-41. doi: 10.1002/1873-3468.12155. Epub 2016 Apr 6.
MGP is a protein that was initially associated with the inhibition of calcification in skeleton, soft tissues, and arteries, but more recently also implicated in cancer. In breast cancer, higher levels of MGP mRNA were associated with poor prognosis, but since this deregulation was never demonstrated at the protein level, we postulated the involvement of a post-transcriptional regulatory mechanism. In this work we show that MGP is significantly repressed by miR-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness. This study brings new insights into the putative involvement of MGP and oncomiR-155 in breast cancer, and may contribute to develop new therapeutic strategies.
基质Gla蛋白（MGP）是一种最初与骨骼、软组织和动脉钙化抑制相关的蛋白质，但最近也被认为与癌症有关。在乳腺癌中，较高水平的MGP信使核糖核酸（mRNA）与预后不良相关，但由于这种失调从未在蛋白质水平得到证实，我们推测存在转录后调控机制。在这项研究中，我们发现MGP在乳腺癌MCF-7细胞中被微小核糖核酸-155（miR-155）显著抑制，同时伴随着细胞增殖和细胞侵袭能力的增强。这项研究为MGP和致癌miR-155在乳腺癌中的假定作用带来了新的见解，并可能有助于开发新的治疗策略。
