鸡骨水解物美拉德反应产物的安全性评价。
Safety assessment of Maillard reaction products of chicken bone hydrolysate using Sprague-Dawley rats.
机构信息
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China;
出版信息
Food Nutr Res. 2016 Mar 23;60:27827. doi: 10.3402/fnr.v60.27827. eCollection 2016.
BACKGROUND
The Maillard reaction products of chicken bone hydrolysate (MRPB) containing 38% protein, which is a derived product from chicken bone, is usually used as a flavor enhancer or food ingredient. In the face of a paucity of reported data regarding the safety profile of controversial Maillard reaction products, the potential health effects of MRPB were evaluated in a subchronic rodent feeding study.
METHODS
Sprague-Dawley rats (SD, 5/sex/group) were administered diets containing 9, 3, 1, or 0% of MRPB derived from chicken bone for 13 weeks.
RESULTS
During the 13-week treatment period, no mortality occurred, and no remarkable changes in general condition and behavior were observed. The consumption of MRPB did not have any effect on body weight or feed and water consumption. At the same time, there was no significant increase in the weights of the heart, liver, lung, kidney, spleen, small intestine, and thymus in groups for both sexes. Serological examination showed serum alanine aminotransferase in both sexes was decreased significantly, indicating liver cell protection. No treatment-related histopathological differences were observed between the control and test groups.
CONCLUSION
Based on the results of this study, the addition of 9% MRPB in the diet had no adverse effect on both male and female SD rats during the 90-day observation. Those results would provide useful information on the safety of a meaty flavor enhancer from bone residue as a byproduct of meat industry.
背景
鸡骨水解产物的美拉德反应产物（MRPB）含有 38%的蛋白质，是鸡骨的衍生产品，通常用作增味剂或食品成分。鉴于备受争议的美拉德反应产物的安全性数据匮乏，本研究采用亚慢性啮齿动物喂养试验来评估 MRPB 的潜在健康影响。
方法
Sprague-Dawley 大鼠（SD，每组 5 只，雌雄各半）喂食含 9%、3%、1%或 0%鸡骨来源的 MRPB 的饮食 13 周。
结果
在为期 13 周的治疗期间，无大鼠死亡，且一般状况和行为无明显变化。MRPB 的摄入对体重或饲料和水的消耗没有影响。同时，雌雄大鼠的心、肝、肺、肾、脾、小肠和胸腺重量均无显著增加。血清学检查显示，雌雄大鼠血清丙氨酸氨基转移酶均显著降低，提示具有肝细胞保护作用。各试验组与对照组之间未观察到与处理相关的组织病理学差异。
结论
基于该研究结果，在 90 天的观察期内，饮食中添加 9%的 MRPB 对雌雄 SD 大鼠没有不良影响。这些结果为肉类风味增强剂（源自肉骨剩余物）作为肉类工业的副产品的安全性提供了有用信息。
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