March Rosselló Gabriel Alberto, Mora Arturo Artero, Pérez Rubio Alberto, Eiros Bouza José María
Service of Microbiology and Immunology, University Clinic Hospital of Valladolid, Spain.
Faculty of Medicine, University of Valencia, Spain.
Infez Med. 2016;24(1):18-23.
The overuse and misuse of antimicrobials contribute to the emergence of antibiotic-resistant bacteria. The aim of this work was to analyse all the anti-infectives for systemic use (J ATC group) prescribed at the University Clinic Hospital of Valladolid (Spain) for the years 2009-2013. Amounts of anti-infectives (antibacterials, antifungals and antivirals) used in the period 2009-2013 were expressed as defined daily doses (DDDs) and as total expenditure, and the significance of the difference in consumption of anti-infectives and the relevant expenditure between years was evaluated from the overlapping of the corresponding confidence intervals at 95% confidence level of DDDs and expenditure. The results obtained showed that DDDs and expenditure of antibacterials decreased in the period 2009-2013. Antimycotics showed an upward trend in expenditure and DDDs in the five-year study period, but with major oscillations. The consumption of antivirals was practically constant in the period 2009-2011; in 2012, a significant reduction was observed and this reduction was conserved in 2013, although their expenditure increased year by year. In conclusion, in the period 2009-2013, expenditure on anti-infectives increased year to year. However, this increase in expenditure resulted in a downward trend of DDDs.
抗菌药物的过度使用和滥用导致了抗生素耐药菌的出现。这项工作的目的是分析2009年至2013年在西班牙巴利亚多利德大学临床医院开具的所有全身用抗感染药物（《解剖治疗学化学分类系统》J类）。2009年至2013年期间使用的抗感染药物（抗菌药、抗真菌药和抗病毒药）数量以限定日剂量（DDD）和总支出表示，并通过95%置信水平的DDD和支出相应置信区间的重叠来评估各年份抗感染药物消费差异及相关支出的显著性。所得结果表明，2009年至2013年期间抗菌药的DDD和支出有所下降。在为期五年的研究期内，抗真菌药的支出和DDD呈上升趋势，但波动较大。2009年至2011年期间抗病毒药的消费量基本保持不变；2012年观察到显著下降，2013年这一下降趋势持续，尽管其支出逐年增加。总之，在2009年至2013年期间，抗感染药物的支出逐年增加。然而，这种支出的增加导致了DDD呈下降趋势。
