The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia.
作者信息
Wojtuszkiewicz Anna, Assaraf Yehuda G, Hoekstra Mirthe, Sciarrillo Rocco, Jansen Gerrit, Peters Godefridus J, Pieters Rob, Sonneveld Edwin, Escherich Gabriele, Kaspers Gertjan J L, Cloos Jacqueline
机构信息
Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands.
Dept. of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
出版信息
Haematologica. 2016 Jul;101(7):e291-4. doi: 10.3324/haematol.2016.142794. Epub 2016 Apr 1.
Abstract
摘要
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Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.
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Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.
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