结直肠癌组织及癌旁黏膜中胃泌素的免疫组织化学研究
Immunohistochemical study of gastrin in colorectal carcinoma tissues and adjacent mucosa.
作者信息
Jiang C P, Chen Y Q, Zhu J W, Shen H X, Yu X
机构信息
Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China.
出版信息
World J Gastroenterol. 1997 Jun 15;3(2):84-6. doi: 10.3748/wjg.v3.i2.84.
AIM
To study gastrin expression in colorectal carcinoma tissues and adjacent mucosa and discuss the function of gastrin in colorectal carcinoma.
METHODS
Gastrin expression in colorectal carcinoma tissues and adjacent mucosa was examined in 58 cases using immunohistochemical and immunoelectron microscopy.
RESULTS
A total of 35.1% of colorectal carcinoma transitional mucosa (TM), 48.3% of nontypical dysplasia mucosa and 60.3% of carcinoma tissue were positive for gastrin expression (P < 0.05). Immunoelectron microscopy revealed that protein A gold (PAG) granules localized to different electron-dense secretory granules in carcinoma cells, the intercellular spaces, and the microvillar membrane surface.
CONCLUSION
Gastrin expression in colorectal carcinoma tissue and adjacent mucosa, and the release of gastrin by carcinoma may be an initiating factor in carcinoma occurrence and development. Positive gastrin expression in colorectal carcinoma tissues can serve as a differentiation marker.
目的
研究胃泌素在结直肠癌组织及癌旁黏膜中的表达情况，并探讨胃泌素在结直肠癌中的作用。
方法
采用免疫组织化学和免疫电子显微镜技术检测58例结直肠癌组织及癌旁黏膜中胃泌素的表达。
结果
胃泌素表达阳性率在结直肠癌移行黏膜（TM）中为35.1%，在非典型增生黏膜中为48.3%，在癌组织中为60.3%（P<0.05）。免疫电子显微镜显示，蛋白A金（PAG）颗粒定位于癌细胞、细胞间隙及微绒毛膜表面不同电子密度的分泌颗粒中。
结论
胃泌素在结直肠癌组织及癌旁黏膜中的表达，以及癌细胞释放胃泌素可能是癌发生发展的启动因素。结直肠癌组织中胃泌素表达阳性可作为一种分化标志物。
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