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初诊血液透析患者动静脉内瘘建立的结局、术前静脉造影的效果及内瘘成功的预测因素:单中心经验

Outcomes of arteriovenous fistula creation, effect of preoperative vein mapping and predictors of fistula success in incident haemodialysis patients: A single-centre experience.

作者信息

Lee Kian-Guan, Chong Tze-Tec, Goh Nicholette, Achudan Shaam, Tan Yi-Liang, Tan Ru-Yu, Choong Hui-Lin, Tan Chieh-Suai

机构信息

Department of Renal Medicine, Singapore General Hospital, Singapore.

Department of Vascular Surgery, Singapore General Hospital, Singapore.

出版信息

Nephrology (Carlton). 2017 May;22(5):382-387. doi: 10.1111/nep.12788.

Abstract

AIM

Vascular access in haemodialysis is critical for effective therapy. We aim to evaluate the outcomes of arteriovenous fistula (AVF) creation in incident haemodialysis patients, impact of preoperative vein mapping and predictors of successful AVF maturation in our centre.

METHODS

Data of End-stage Renal Disease (ESRD) patients initiated on haemodialysis from January 2010 to December 2012 in our centre were retrospectively obtained from electronic medical records and clinical notes. Demographic characteristics, medical comorbidities, perioperative details were collected, and patients were followed up until 1 January 2014.

RESULTS

A total of 708 patients (median age 64, IQR 55-72) were included with mean duration of follow up of 2.3 ± 1.2 years, with access of AVF and arteriovenous graft (AVG) in 694 (98%) and 14 (2%) patients respectively. Eight patients were lost to follow-up. Successful AVF maturation was achieved in 542 patients (78%), with 1-year cumulative patency rate of 74%. Multivariate analysis revealed male gender, upper arm AVF and good postoperative thrill and pulse as predictors of successful AVF maturation. Preoperative vein mapping was performed in 42.5% (295/694) of patients, with mean vein diameter of 2.44 ± 0.82 mm. Maturation rates with and without vein mapping were 72.2% and 82.4%, respectively, (P = 0.001). In patients with vein diameters of <2 mm and ≥2 mm, there was no statistically significant difference in maturation rates (71.3% vs. 72.6%; P = 0.887) and median maturation time (66 vs. 78 days; P = 0.73).

CONCLUSION

Arteriovenous fistula can be successfully created in most incident haemodialysis patients. Routine vein mapping is not necessary if veins are suitable on physical examination alone, and vein sizes of <2 mm on ultrasound is not associated with lower AVF maturation rate.

摘要

目的

血液透析中的血管通路对于有效治疗至关重要。我们旨在评估初治血液透析患者动静脉内瘘(AVF)建立的结果、术前静脉造影的影响以及我们中心AVF成功成熟的预测因素。

方法

回顾性收集2010年1月至2012年12月在我们中心开始进行血液透析的终末期肾病(ESRD)患者的数据,这些数据来自电子病历和临床记录。收集人口统计学特征、合并症、围手术期细节,并对患者进行随访直至2014年1月1日。

结果

共纳入708例患者(中位年龄64岁,四分位间距55 - 72岁),平均随访时间为2.3±1.2年,其中694例(98%)患者建立了AVF,14例(2%)患者建立了动静脉移植物(AVG)。8例患者失访。542例患者(78%)实现了AVF的成功成熟,1年累积通畅率为74%。多因素分析显示,男性、上臂AVF以及术后良好的震颤和脉搏是AVF成功成熟的预测因素。42.5%(295/694)的患者进行了术前静脉造影,平均静脉直径为2.44±0.82毫米。有和没有静脉造影的成熟率分别为72.2%和82.4%(P = 0.001)。静脉直径<2毫米和≥2毫米的患者,成熟率(71.3%对72.6%;P = 0.887)和中位成熟时间(66天对78天;P = 0.73)无统计学显著差异。

结论

大多数初治血液透析患者能够成功建立动静脉内瘘。如果仅通过体格检查静脉合适,则无需常规进行静脉造影,超声显示静脉直径<2毫米与较低的AVF成熟率无关。

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