Avila-Funes J A, Medina-Campos R H, Tamez-Rivera O, Navarrete-Reyes A P, Amieva H, Aguilar-Navarro S
José Alberto Ávila-Funes, MD, PhD. Department of Geriatrics. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga 15. CP 14000; Tlalpan, Distrito Federal, México. Phone: +52 (55) 5487-0900, ext. 5703. E-mail:
J Frailty Aging. 2014;3(4):206-10. doi: 10.14283/jfa.2014.25.
The phenotype of frailty proposed by Fried et al has shown to predict several adverse health-related outcomes in elderly populations worldwide; however, the description of such associations in Latin America is still scarce.
To describe the association between frailty and recent hospitalization, disability for basic (ADL) and instrumental activities of daily living (IADL).
DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study of 1,124 community-dwelling adults aged 70 and older participating in the Coyoacán cohort.
Frailty was defined by the presence of at least three of the following criteria: weight loss, exhaustion, low physical activity, slowness, and weakness. Multiple regression analyses were used to test the association between frailty and the outcomes of interest, adjusting for potential confounders.
Mean age was 78.2 (SD ±6.1) years. Prevalence of frailty was 14.1%. Adjusted multivariate models showed that frail status was associated with ADL disability (OR 3.06, 95%CI 1.52-6.17), IADL disability (OR 17.02, 95%CI 6.16-47.01), and recent hospitalization (OR 3.21, 95%CI 1.31-7.8).
Among Mexican community-dwelling elderly, frailty is associated with ADL and IADL disability as well as with recent hospitalizations. Moreover, frailty's prevalence in this population appears to be greater compared to what has been reported elsewhere. Social and cultural traits should be further studied as correlates of frailty in diverse populations.
弗里德等人提出的衰弱表型已被证明可预测全球老年人群中几种与健康相关的不良结局；然而，拉丁美洲关于此类关联的描述仍然很少。
描述衰弱与近期住院、基本日常生活活动（ADL）残疾和工具性日常生活活动（IADL）残疾之间的关联。
设计、设置和参与者：对1124名年龄在70岁及以上的社区居住成年人进行横断面研究，这些成年人参与了科约阿坎队列研究。
衰弱定义为存在以下至少三项标准：体重减轻、疲惫、身体活动量低、行动迟缓及虚弱。使用多元回归分析来检验衰弱与感兴趣的结局之间的关联，并对潜在混杂因素进行调整。
平均年龄为78.2（标准差±6.1）岁。衰弱患病率为14.1%。调整后的多变量模型显示，衰弱状态与ADL残疾（比值比3.06，95%置信区间1.52 - 6.17）、IADL残疾（比值比17.02，95%置信区间6.16 - 47.01）以及近期住院（比值比3.21，95%置信区间1.31 - 7.8）相关。
在墨西哥社区居住的老年人中，衰弱与ADL和IADL残疾以及近期住院相关。此外，与其他地方报道的情况相比，该人群中衰弱的患病率似乎更高。社会和文化特征应作为不同人群中衰弱的相关因素进一步研究。
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