Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden.
J Gerontol B Psychol Sci Soc Sci. 2017 Oct 1;72(6):1044-1053. doi: 10.1093/geronb/gbw043.
To investigate the associations between midlife work-related stress and mild cognitive impairment (MCI), dementia, and Alzheimer's disease later in life, in a large representative population.
Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study participants were randomly selected from independent population-based surveys (mean age 50 years). A random sample of 2,000 individuals was invited for two reexaminations including cognitive tests (at mean age 71 and mean age 78), and 1,511 subjects participated in at least one reexamination (mean follow-up 28.5 years). Work-related stress was measured using two questions on work demands that were administered in midlife. Analyses adjusted for important confounders.
Higher levels of midlife work-related stress were associated with higher risk of MCI (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.08-1.76), dementia (OR, 1.53; CI, 1.13-2.07), and Alzheimer's disease (OR, 1.55; CI, 1.19-2.36) at the first follow-up among the CAIDE participants. Results remained significant after adjusting for several possible confounders. Work-related stress was not associated with MCI and dementia during the extended follow-up.
Midlife work-related stress increases the risk for MCI, dementia, and Alzheimer's disease in later life. The association was not seen after the extended follow-up possibly reflecting selective survival/participation, heterogeneity in dementia among the oldest old, and a critical time window for the effects of midlife stress.
在一个大型代表性人群中，调查中年与工作相关的压力与轻度认知障碍（MCI）、痴呆症和阿尔茨海默病之间的关联。
心血管风险因素、衰老和痴呆症（CAIDE）研究参与者是从独立的基于人群的调查中随机选择的（平均年龄 50 岁）。邀请了 2000 名随机样本进行两次复查，包括认知测试（平均年龄 71 岁和平均年龄 78 岁），其中 1511 名参与者至少参加了一次复查（平均随访 28.5 年）。中年时使用两个关于工作要求的问题来衡量与工作相关的压力。分析调整了重要的混杂因素。
与工作相关的压力较高与 MCI（优势比[OR]，1.38；95%置信区间[CI]，1.08-1.76）、痴呆症（OR，1.53；CI，1.13-2.07）和阿尔茨海默病（OR，1.55；CI，1.19-2.36）的风险较高相关，这在 CAIDE 参与者的第一次随访中是如此。在调整了几个可能的混杂因素后，结果仍然显著。与工作相关的压力与延长随访期间的 MCI 和痴呆症无关。
中年与工作相关的压力增加了晚年 MCI、痴呆症和阿尔茨海默病的风险。在延长随访后没有发现这种关联，这可能反映了选择性生存/参与、最年长人群中痴呆症的异质性，以及中年压力影响的关键时间窗口。
